656428.fig.002
Figure 2: Our proposed model of PPARα effect on CYP2C and CYP2J (simplified): activation of PPARα results in CYP2C and CYP2J expression. CYP2C and CYP2J convert arachidonic acid (AA) to EETs, which have cytoprotective function and also can serve as PPARα ligand, resulting in feedback mechanism. CYP2C and CYP2J also metabolise xenobiotics.