Table 2: Summary of CYP2C and CYP2J2 expression in normal adult tissues. Expression levels estimated at protein and mRNA level [23, 25].

TissueCYP proteinCYP mRNA

Gastrointestinal system
 Salivary glandsCYP2C8, CYP2C9CYP2C8, CYP2C18, CYP2C19, CYP2J2
 StomachCYP2C9
 LiverCYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 PancreasCYP2C9, CYP2J2
 Small intestineCYP2C8, CYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 Large intestineCYP2C8, CYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Urinary system
 BladderCYP2C8, CYP2C18, CYP2J2
 Kidney CYP2C8, CYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Endocrine system
 AdrenalsCYP2C8, CYP2C9CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 Pituitary glandCYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2J2
Cardiovascular system
 MyocardiumCYP2C9, CYP2J2CYP2C8, CYP2J2
Lymphoid tissues
 TonsilsCYP2C8, CYP2C9
 SpleenCYP2C9CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 Lymphatic nodesCYP2C9
 ThymusCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Respiratory system
 TracheaCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 LungCYP2C9, CYP2J2CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Skin
 EpidermisCYP2C9
 Mammary glandCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Reproductive system
 EndometriumCYP2C9
 OvaryCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 uterusCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 placentaCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 prostateCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
 testesCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2
Musculoskeletal system
 bone marrowCYP2C8, CYP2C18, CYP2J2
 skeleton muscleCYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2J2