Development of Tyrosine-Based Radiotracer ^𝟗𝟗𝐦Tc-N4-Tyrosine for Breast Cancer Imaging

Table 2

Absorbed radiation dose estimates (dose per unit injected into a 70 kg adult man) for ^99mTc-N4-Tyrosine.

Target organ	Absorbed radiation dose estimates		Human dose (15 mCi)
	mSv/MBq	rem/mCi	rem
Adrenals	4.65𝐸−03	1.72𝐸−02	2.58𝐸−01
Brain	4.69𝐸−04	1.74𝐸−03	2.61𝐸−02
Breasts	1.27𝐸−03	4.72𝐸−03	7.08𝐸−02
Gallbladder wall	3.79𝐸−03	1.40𝐸−02	2.10𝐸−01
Lower large intestine wall	1.62𝐸−03	6.00𝐸−03	9.00𝐸−02
Small intestine	2.70𝐸−03	1.00𝐸−02	1.50𝐸−01
Stomach wall	2.49𝐸−03	9.21𝐸−03	1.38𝐸−01
Upper large intestine wall	2.44𝐸−03	9.04𝐸−03	1.36𝐸−01
Heart wall	8.51𝐸−03	3.15𝐸−02	4.73𝐸−01
Kidneys	4.86𝐸−02	1.80𝐸−01	2.70𝐸+00
Liver	5.52𝐸−03	2.04𝐸−02	3.06𝐸−01
Lungs	2.27𝐸−03	8.41𝐸−03	1.26𝐸−01
Muscle	1.34𝐸−03	4.96𝐸−03	7.44𝐸−02
Ovaries	1.76𝐸−03	6.53𝐸−03	9.80𝐸−02
Pancreas	3.76𝐸−03	1.39𝐸−02	2.09𝐸−01
Red marrow	1.91𝐸−03	7.07𝐸−03	1.06𝐸−01
Osteogenic cells	5.21𝐸−03	1.93𝐸−02	2.90𝐸−01
Skin	8.91𝐸−04	3.30𝐸−03	4.95𝐸−02
Spleen	5.66𝐸−03	2.09𝐸−02	3.14𝐸−01
Testes	7.91𝐸−04	2.93𝐸−03	4.40𝐸−02
Thymus	2.29𝐸−03	8.47𝐸−03	1.27𝐸−01
Thyroid	1.25𝐸−03	4.61𝐸−03	6.92𝐸−02
Urinary bladder wall	1.39𝐸−03	5.14𝐸−03	7.71𝐸−02
Uterus	1.77𝐸−03	6.53𝐸−03	9.80𝐸−02
Total Body	1.98𝐸−03	7.32𝐸−03	1.10𝐸−01
Effective dose equivalent	5.71𝐸−03	2.11𝐸−02	3.17𝐸−01
Effective dose	2.19𝐸−03	8.11𝐸−03	1.22𝐸−01