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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 672760, 9 pages
http://dx.doi.org/10.1155/2012/672760
Review Article

Therapeutic Strategies Based on Polymeric Microparticles

1Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello, Santiago, Echaurren 183, 8370071 Santiago, Chile
2Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Avenida Ecuador 3493, 9170124 Santiago, Chile

Received 14 December 2011; Revised 28 February 2012; Accepted 13 March 2012

Academic Editor: Soldano Ferrone

Copyright © 2012 C. Vilos and L. A. Velasquez. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development of the field of materials science, the ability to perform multidisciplinary scientific work, and the need for novel administration technologies that maximize therapeutic effects and minimize adverse reactions to readily available drugs have led to the development of delivery systems based on microencapsulation, which has taken one step closer to the target of personalized medicine. Drug delivery systems based on polymeric microparticles are generating a strong impact on preclinical and clinical drug development and have reached a broad development in different fields supporting a critical role in the near future of medical practice. This paper presents the foundations of polymeric microparticles based on their formulation, mechanisms of drug release and some of their innovative therapeutic strategies to board multiple diseases.