Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balb/c Mice

Table 3

Results of histopathological investigations of mice following repeated recombinant PfP0 administrations.

Organ	Severity	Changes observed
Liver	+++	Severe swelling and derangement of cords, infiltration of mononuclear cells around the portal triad
Kidneys	+++	Tubular necrosis and diffuse necrotic changes along with infiltration of inflammatory cells around the necrotic area
Lungs	+++	Edema, congestion, MNC infiltration, diffuse interstitial and patchy pneumonia
Heart	+	Mild congestion and swelling of fibres
Spleen	+++	Loss of lymphoid cells, replaced by connective tissue
Brain	−	No abnormality detected

−: negative, +: mild, +++: severe.