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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 718617, 13 pages
http://dx.doi.org/10.1155/2012/718617
Review Article

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Institute of Pathology, Medical Experimental Centre, Medical Faculty, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia

Received 9 December 2011; Accepted 5 March 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 Martina Perše and Anton Cerar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology. Thus, dozens of different animal models of IBD have been developed in past decades. Animal models of IBD are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of IBD and to evaluate different therapeutic options. However, the dextran sulphate sodium (DSS-) induced colitis model has some advantages when compared to other animal models of colitis. It is well appreciated and widely used model of inflammatory bowel disease because of its simplicity. It has many similarities to human IBD, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using DSS model. As demonstrated in the present paper, various factors may affect susceptibility to DSS-induced lesions and modify results.