About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 718617, 13 pages
http://dx.doi.org/10.1155/2012/718617
Review Article

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Institute of Pathology, Medical Experimental Centre, Medical Faculty, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia

Received 9 December 2011; Accepted 5 March 2012

Academic Editor: Oreste Gualillo

Copyright © 2012 Martina Perše and Anton Cerar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [138 citations]

The following is the list of published articles that have cited the current article.

  • M. D. Trottier, R. Irwin, Y. Li, L. R. McCabe, and P. J. Fraker, “Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis,” Proceedings of the National Academy of Sciences, vol. 109, no. 41, pp. 16594–16599, 2012. View at Publisher · View at Google Scholar
  • Yunliang Yao, Wenzheng Han, Jingjing Liang, Jian Ji, Jianli Wang, Harvey Cantor, and Linrong Lu, “ Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8 + regulatory cells ,” European Journal of Immunology, vol. 43, no. 1, pp. 125–136, 2012. View at Publisher · View at Google Scholar
  • Felicitas L Koller, E Ashley Dozier, Ki Taek Nam, Mei Swee, Timothy P Birkland, William C Parks, and Barbara Fingleton, “Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia,” Laboratory Investigation, vol. 92, no. 12, pp. 1749–1759, 2012. View at Publisher · View at Google Scholar
  • Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Seon Hee Choi, Soon Cheol Ahn, and Hak Sun Yu, “ Trichinella spiralis Infection Suppressed Gut Inflammation with CD4 + CD25 + Foxp3 + T Cell Recruitment ,” The Korean Journal of Parasitology, vol. 50, no. 4, pp. 385, 2012. View at Publisher · View at Google Scholar
  • Shih-Ping Hung, Ming-Jen Sheu, Ming Chieh Ma, Jui-Ting Hu, Ya-Yun Sun, Chin-Cheng Lee, Yuan-Chiang Chung, Yi-Ju Tsai, Jing-Yuan Wang, and Chih-Li Chen, “Runx1-Deficient Afferents Impair Visceral Nociception, Exacerbating Dextran Sodium Sulfate-Induced Colitis,” Brain, Behavior, and Immunity, 2013. View at Publisher · View at Google Scholar
  • Sabina A. Mir, Dorottya Nagy-Szakal, Scot E. Dowd, Reka G. Szigeti, and C. Wayne Smith, “Prenatal Methyl-Donor Supplementation Augments Colitis in Young Adult Mice,” Plos One, vol. 8, no. 8, 2013. View at Publisher · View at Google Scholar
  • Mary E. Morgan, Bin Zheng, Pim J. Koelink, Hendrick J. G. van de Kant, Lizette C. J. M. Haazen, Manon van Roest, Johan Garssen, Gert Folkerts, and Aletta D. Kraneveld, “New Perspective on Dextran Sodium Sulfate Colitis: Antigen-Specific T Cell Development during Intestinal Inflammation,” PLoS ONE, vol. 8, no. 7, 2013. View at Publisher · View at Google Scholar
  • Daniela Börnigen, Xochitl C. Morgan, Eric A. Franzosa, Boyu Ren, Ramnik J. Xavier, Wendy S. Garrett, and Curtis Huttenhower, “Functional profiling of the gut microbiome in disease-associated inflammation,” Genome Medicine, vol. 5, no. 7, 2013. View at Publisher · View at Google Scholar
  • Giovanni Dothel, Valentina Vasina, Giovanni Barbara, and Fabrizio De Ponti, “Animal models of chemically induced intestinal inflammation: Predictivity and ethical issues,” Pharmacology & Therapeutics, vol. 139, no. 1, pp. 71–86, 2013. View at Publisher · View at Google Scholar
  • Bénédicte Brounais-Le Royer, Dominique D. Pierroz, Dominique Velin, Christophe Frossard, Xin Xiao Zheng, Hans-Anton Lehr, Sylvie Ferrari-Lacraz, and Serge L. Ferrari, “Effects of an Interleukin-15 Antagonist on Systemic and Skeletal Alterations in Mice with DSS-Induced Colitis,” The American Journal of Pathology, vol. 182, no. 6, pp. 2155–2167, 2013. View at Publisher · View at Google Scholar
  • Marc D. Cook, Stephen A. Martin, Collette Williams, Keith Whitlock, Matthew A. Wallig, Brandt A. Pence, and Jeffrey A. Woods, “Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis,” Brain, Behavior, and Immunity, 2013. View at Publisher · View at Google Scholar
  • Leslie Knod, Eileen C. Donovan, Artur Chernoguz, Kelly M. Crawford, Mary R. Dusing, and Jason S. Frischer, “Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis,” Journal of Surgical Research, 2013. View at Publisher · View at Google Scholar
  • Fangcong Dong, Lulu Zhang, Fuhua Hao, Huiru Tang, and Yulan Wang, “ Systemic Responses of Mice to Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis Using 1 H NMR Spectroscopy ,” Journal of Proteome Research, pp. 130517081622002, 2013. View at Publisher · View at Google Scholar
  • Carla Petrella, Chiara Giuli, Maria Broccardo, Helene Eutamene, Christel Cartier, Mathilde Leveque, Andrea Bedini, Santi Spampinato, Lionel Bueno, Vassilia Theodorou, Giovanna Improta, and Simona Agostini, “Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis,” Pharmacological Research, vol. 70, no. 1, pp. 72–79, 2013. View at Publisher · View at Google Scholar
  • Christine Dejea, Elizabeth Wick, and Cynthia L Sears, “Bacterial oncogenesis in the colon,” Future Microbiology, vol. 8, no. 4, pp. 445–460, 2013. View at Publisher · View at Google Scholar
  • Feifei Tao, Cheng Qian, Wenjie Guo, Qiong Luo, Qiang Xu, and Yang Sun, “Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin,” Biochemical Pharmacology, vol. 85, no. 6, pp. 798–807, 2013. View at Publisher · View at Google Scholar
  • Audrey Seamons, Piper M. Treuting, Thea Brabb, and Lillian Maggio-Price, “Characterization of Dextran Sodium Sulfate-Induced Inflammation and Colonic Tumorigenesis in Smad3(-/-) Mice with Dysregulated TGF beta,” Plos One, vol. 8, no. 11, 2013. View at Publisher · View at Google Scholar
  • Yosuke Shimada, Makoto Kinoshita, Kazuo Harada, Masafumi Mizutani, Kazunori Masahata, Hisako Kayama, and Kiyoshi Takeda, “Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon,” Plos One, vol. 8, no. 11, 2013. View at Publisher · View at Google Scholar
  • Basalingappa M. Kanthesh, Geoffrey I. Sandle, and Vazhaikkurichi M. Rajendran, “Enhanced K+ secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K+ channels (BK; Kcnma1),” American Journal of Physiology-Cell Physiology, vol. 305, no. 9, pp. C972–C980, 2013. View at Publisher · View at Google Scholar
  • Marta Marin, Rosa Maria Giner, Jose-Luis Rios, and Maria del Carmen Recio, “Protective Effect of Apocynin in a Mouse Model of Chemically-Induced Colitis,” Planta Medica, vol. 79, no. 15, pp. 1392–1400, 2013. View at Publisher · View at Google Scholar
  • Takukyu Sha, Keiko Igaki, Masashi Yamasaki, Takeshi Watanabe, and Noboru Tsuchimori, “Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice,” International Immunopharmacology, vol. 15, no. 1, pp. 23–29, 2013. View at Publisher · View at Google Scholar
  • Philipp Lenz, Dominik Bettenworth, Philipp Krausewitz, Markus Brückner, Steffi Ketelhut, Gert von Bally, Dirk Domagk, and Björn Kemper, “Digital holographic microscopy quantifies the degree of inflammation in experimental colitis,” Integrative Biology, vol. 5, no. 3, pp. 624, 2013. View at Publisher · View at Google Scholar
  • E Macho-Fernandez, E P Koroleva, C M Spencer, M Tighe, E Torrado, A M Cooper, Y-X Fu, and A V Tumanov, “Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells,” Mucosal Immunology, 2014. View at Publisher · View at Google Scholar
  • Liya Zhang, Yanjie Zhang, Wenwei Zhong, Caixia Di, Xiaoliang Lin, and Zhenwei Xia, “Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance,” Journal of Biological Chemistry, vol. 289, no. 39, pp. 26847–26858, 2014. View at Publisher · View at Google Scholar
  • Shelley B. Weisser, Lisa K. Kozicky, Hayley K. Brugger, Eyler N. Ngoh, Bonnie Cheung, Roger Jen, Susan C. Menzies, Asanga Samarakoon, Peter J. Murray, C. James Lim, Pauline Johnson, Jean-Luc Boucher, Nico van Rooijen, and Laura M. Sly, “Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation,” European Journal of Immunology, 2014. View at Publisher · View at Google Scholar
  • Jan Sommer, Erika Engelowski, Paul Baran, Christoph Garbers, Doreen M. Floss, and Juergen Scheller, “Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis,” International Journal of Molecular Medicine, vol. 34, no. 3, pp. 651–660, 2014. View at Publisher · View at Google Scholar
  • Xiao Xiao, Jonggun Kim, Quancai Sun, Daeyoung Kim, Cheon-Seok Park, Tzong-Shi Lu, and Yeonhwa Park, “Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice,” Food Chemistry, 2014. View at Publisher · View at Google Scholar
  • Nidhi Goyal, Ajay Rana, Abhilasha Ahlawat, Krishna Reddy V. Bijjem, and Puneet Kumar, “Animal models of inflammatory bowel disease: a review,” Inflammopharmacology, 2014. View at Publisher · View at Google Scholar
  • Marianna Parlato, and Garabet Yeretssian, “NOD-Like Receptors in Intestinal Homeostasis and Epithelial Tissue Repair,” International Journal of Molecular Sciences, vol. 15, no. 6, pp. 9594–9627, 2014. View at Publisher · View at Google Scholar
  • Tiago Rodrigues-Sousa, Ana Filipa Ladeirinha, Ana Raquel Santiago, Helena Carvalheiro, Bruno Raposo, Ana Alarcao, Antonio Cabrita, Rikard Holmdahl, Lina Carvalho, and M. Margarida Souto-Carneiro, “Deficient Production of Reactive Oxygen Species Leads to Severe Chronic DSS-Induced Colitis in Ncf1/p47(phox)-Mutant Mice,” Plos One, vol. 9, no. 5, 2014. View at Publisher · View at Google Scholar
  • Ye Yang, Sarah Tomkovich, and Christian Jobin, “Could a Swimming Creature Inform Us on Intestinal Diseases? Lessons from Zebrafish,” Inflammatory Bowel Diseases, vol. 20, no. 5, pp. 956–966, 2014. View at Publisher · View at Google Scholar
  • Amr M. Ghaleb, Hamed Laroui, Didier Merlin, and Vincent W. Yang, “Genetic Deletion of Klf4 in the Mouse Intestinal Epithelium Ameliorates Dextran Sodium Sulfate-induced Colitis by Modulating the NF-kappa B Pathway Inflammatory Response,” Inflammatory Bowel Diseases, vol. 20, no. 5, pp. 811–820, 2014. View at Publisher · View at Google Scholar
  • Sam X. Cheng, Yaíma L. Lightfoot, Tao Yang, Mojgan Zadeh, Lieqi Tang, Bikash Sahay, Gary P. Wang, Jennifer L. Owen, and Mansour Mohamadzadeh, “Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses,” FEBS Letters, 2014. View at Publisher · View at Google Scholar
  • Lia Paola Zambetti, and Alessandra Mortellaro, “NLRPs, microbiota, and gut homeostasis: unravelling the connection,” The Journal of Pathology, 2014. View at Publisher · View at Google Scholar
  • Catherine Felgines, Didier Fraisse, Catherine Besson, Marie-Paule Vasson, and Odile Texier, “Bioavailability of lemon verbena (Aloysia triphylla) polyphenols in rats: impact of colonic inflammation,” British Journal of Nutrition, vol. 111, no. 10, pp. 1773–1781, 2014. View at Publisher · View at Google Scholar
  • Bo Xiao, Hamed Laroui, Emilie Viennois, Saravanan Ayyadurai, Moiz A. Charania, Yuchen Zhang, Zhan Zhang, Mark T. Baker, Benyue Zhang, Andrew T. Gewirtz, and Didier Merlin, “Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice,” Gastroenterology, vol. 146, no. 5, pp. 1289–+, 2014. View at Publisher · View at Google Scholar
  • Yuli Lin, Xuguang Yang, Wenjie Yue, Xiaofei Xu, Bingji Li, Linlin Zou, and Rui He, “Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization,” Cellular and Molecular Immunology, 2014. View at Publisher · View at Google Scholar
  • Mohamed E. Shaker, Sylvia A. Ashamallah, and Maha E. Houssen, “Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis,” Chemico-Biological Interactions, vol. 210, pp. 26–33, 2014. View at Publisher · View at Google Scholar
  • Yongwoo Jang, and Uhtaek Oh, “Anoctamin 1 in Secretory Epithelia,” Cell Calcium, 2014. View at Publisher · View at Google Scholar
  • Lindsey Devisscher, Pieter Hindryckx, Michael A Lynes, Anouk Waeytens, Claude Cuvelier, Filip De Vos, Christian Vanhove, Martine De Vos, and Debby Laukens, “Role of metallothioneins as danger signals in the pathogenesis of colitis,” The Journal of Pathology, 2014. View at Publisher · View at Google Scholar
  • T Akimova, H Xiao, Y Liu, T R Bhatti, J Jiao, E Eruslanov, S Singhal, L Wang, R Han, K Zacharia, W W Hancock, and U H Beier, “Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells,” Mucosal Immunology, 2014. View at Publisher · View at Google Scholar
  • Kenta Hino, Atsushi Saito, Rie Asada, Soshi Kanemoto, and Kazunori Imaizumi, “Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Luigia De Fazio, Elena Cavazza, Enzo Spisni, Antonio Strillacci, Manuela Centanni, Marco Candela, Chiara Pratico, Massimo Campieri, Chiara Ricci, and Maria Chiara Valerii, “Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice,” World Journal of Gastroenterology, vol. 20, no. 8, pp. 2051–2061, 2014. View at Publisher · View at Google Scholar
  • C.L. Hayes, J.M.M. Natividad, J. Jury, R. Martin, P. Langella, and E.F. Verdu, “Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration,” Beneficial Microbes, vol. 5, no. 1, pp. 79–88, 2014. View at Publisher · View at Google Scholar
  • Vijay Morampudi, Ganive Bhinder, Xiujuan Wu, Chuanbin Dai, Ho Pan Sham, Bruce A. Vallance, and Kevan Jacobson, “DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat,” Jove-Journal of Visualized Experiments, no. 84, 2014. View at Publisher · View at Google Scholar
  • Chuxin Liu, Liping Xiao, Feida Li, Huanhuan Zhang, Qin Li, Huan Liu, Shujin Fu, Chao Li, Xingju Zhang, Jun Wang, Nicklas H. Staunstrup, Yong Li, and Huanming Yang, “Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation,” Transgenic Research, 2014. View at Publisher · View at Google Scholar
  • Kazushiro Takata, Takayuki Tomita, Tatsusada Okuno, Makoto Kinoshita, Toru Koda, Josephe A. Honorat, Masaya Takei, Kouichiro Hagihara, Tomoyuki Sugimoto, Hideki Mochizuki, Saburo Sakoda, and Yuji Nakatsuji, “Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora,” Annals of Clinical and Translational Neurology, 2014. View at Publisher · View at Google Scholar
  • Ahlem Boussenna, Nicolas Goncalves-Mendes, Juliette Joubert-Zakeyh, Bruno Pereira, Didier Fraisse, Marie-Paule Vasson, Odile Texier, and Catherine Felgines, “Impact of basal diet on dextran sodium sulphate (DSS)-induced colitis in rats,” European Journal of Nutrition, 2014. View at Publisher · View at Google Scholar
  • S.D.A. Elian, E.L.S. Souza, A.T. Vieira, M.M. Teixeira, R.M.E. Arantes, J.R. Nicoli, and F.S. Martins, “Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease,” Beneficial Microbes, vol. 1, no. -1, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Aline Van Acker, Jessica Filtjens, Sophie Van Welden, Sylvie Taveirne, Els Van Ammel, Mandy Vanhees, Lindsey Devisscher, Tessa Kerre, Tom Taghon, Bart Vandekerckhove, Jean Plum, and Georges Leclercq, “Ly49E Expression on CD8 alpha alpha-Expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases,” Plos One, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • John P. Vu, Mulugeta Million, Muriel Larauche, Leon Luong, Joshua Norris, James A. Waschek, Charalabos Pothoulakis, Joseph R. Pisegna, and Patrizia M. Germano, “Inhibition of Vasoactive Intestinal Polypeptide (VIP) Induces Resistance to Dextran Sodium Sulfate (DSS)-Induced Colitis in Mice,” Journal of Molecular Neuroscience, vol. 52, no. 1, pp. 37–47, 2014. View at Publisher · View at Google Scholar
  • Puneet Kaur Randhawa, Kavinder Singh, Nirmal Singh, and Amteshwar Singh Jaggi, “A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents,” The Korean Journal of Physiology & Pharmacology, vol. 18, no. 4, pp. 279, 2014. View at Publisher · View at Google Scholar
  • Madonna R. Peter, Mirjana Jerkic, Valentin Sotov, David N. Douda, Daniela S. Ardelean, Niousha Ghamami, Flavia Lakschevitz, Meraj A. Khan, Susan J. Robertson, Michael Glogauer, Dana J. Philpott, Nades Palaniyar, and Michelle Letarte, “ Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis ,” Mediators of Inflammation, vol. 2014, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  • Carlo De Salvo, Shuvra Ray, and Theresa T. Pizarro, “Mechanisms and Models for Intestinal Fibrosis in IBD,” Digestive Diseases, vol. 32, pp. 26–34, 2014. View at Publisher · View at Google Scholar
  • Hanne Salmenkari, Tomi Issakainen, Heikki Vapaatalo, and Riitta Korpela, “Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation,” World Journal Of Gastroenterology, vol. 21, no. 35, pp. 10072–10079, 2015. View at Publisher · View at Google Scholar
  • Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vengadeshprabhu Karuppagounder, Vigneshwaran Pitchaimani, Rejina Afrin, Meilei Harima, Takashi Nakamura, Kazuyuki Ueno, Masahiko Nakamura, Kenji Suzuki, and Kenichi Watanabe, “Toki-shakuyaku-san, a Japanese kampo medicine, reduces colon inflammation in a mouse model of acute colitis,” International Immunopharmacology, 2015. View at Publisher · View at Google Scholar
  • S Das, S Rachagani, Y Sheinin, L M Smith, C B Gurumurthy, H K Roy, and S K Batra, “Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer,” Oncogene, 2015. View at Publisher · View at Google Scholar
  • Xing Pei Hao, Carissa M. Lucero, Baris Turkbey, Marcelino L. Bernardo, David R. Morcock, Claire Deleage, Charles M. Trubey, Jeremy Smedley, Nichole R. Klatt, Luis D. Giavedoni, Jan Kristoff, Amy Xu, Gregory Q. Del Prete, Brandon F. Keele, Srinivas S. Rao, W. Gregory Alvord, Peter L. Choyke, Jeffrey D. Lifson, Jason M. Brenchley, Cristian Apetrei, Ivona Pandrea, and Jacob D. Estes, “Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection,” Nature Communications, vol. 6, pp. 8020, 2015. View at Publisher · View at Google Scholar
  • Laurel A. Monticelli, Lisa C. Osborne, Mario Noti, Sara V. Tran, Dietmar M. W. Zaiss, and David Artis, “IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions,” Proceedings of the National Academy of Sciences, vol. 112, no. 34, pp. 10762–10767, 2015. View at Publisher · View at Google Scholar
  • Bo Xiao, Xiaoying Si, Mingzhen Zhang, and Didier Merlin, “Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy,” Colloids and Surfaces B: Biointerfaces, 2015. View at Publisher · View at Google Scholar
  • Dongfeng Qu, Nathaniel Weygant, Randal May, Parthasarathy Chandrakesan, Mohammad Madhoun, Naushad Ali, Sripathi M. Sureban, Guangyu An, Michael J. Schlosser, and Courtney W. Houchen, “Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis,” Plos One, vol. 10, no. 8, 2015. View at Publisher · View at Google Scholar
  • Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, and Anthony W. Segal, “Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis,” Disease Models & Mechanisms, vol. 8, no. 8, pp. 817–U491, 2015. View at Publisher · View at Google Scholar
  • Nancy A. Erickson, Elisabeth E. L. Nystrom, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M. Heimesaat, Andre Fischer, Stefan Bereswill, George M. H. Birchenough, Achim D. Gruber, and Malin E. V. Johansson, “The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-C,” Plos One, vol. 10, no. 7, 2015. View at Publisher · View at Google Scholar
  • Dagmar Srutkova, Martin Schwarzer, Tomas Hudcovic, Zuzana Zakostelska, Vladimir Drab, Alena Spanova, Bohuslav Rittich, Hana Kozakova, and Irma Schabussova, “Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner,” Plos One, vol. 10, no. 7, 2015. View at Publisher · View at Google Scholar
  • Piyush Jain, Ahmed M. Hassan, Chintan N. Koyani, Raphaela Mayerhofer, Florian Reichmann, Aitak Farzi, Rufina Schuligoi, Ernst Malle, and Peter Holzer, “Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress,” Frontiers In Behavioral Neuroscience, vol. 9, 2015. View at Publisher · View at Google Scholar
  • A R B M Muzaki, P Tetlak, J Sheng, S C Loh, Y A Setiagani, M Poidinger, F Zolezzi, K Karjalainen, and C Ruedl, “Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells,” Mucosal Immunology, 2015. View at Publisher · View at Google Scholar
  • H L Zhang, Y J Zheng, Y D Pan, C Xie, H Sun, Y H Zhang, M Y Yuan, B L Song, and J F Chen, “Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity,” Mucosal Immunology, 2015. View at Publisher · View at Google Scholar
  • Darshana Poddar, Ravinder Kaur, William M Baldwin, and Barsanjit Mazumder, “L13a-dependent translational control in macrophages limits the pathogenesis of colitis,” Cellular and Molecular Immunology, 2015. View at Publisher · View at Google Scholar
  • Petra Nicken, Anne von Keutz, Ina Willenberg, Annika I. Ostermann, Nils Helge Schebb, Samoa Giovannini, Olivia Kershaw, Gerhard Breves, and Pablo Steinberg, “Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Qi Ying Lean, Rajaraman D. Eri, J. Helen Fitton, Rahul P. Patel, and Nuri Gueven, “Fucoidan Extracts Ameliorate Acute Colitis,” Plos One, vol. 10, no. 6, 2015. View at Publisher · View at Google Scholar
  • Honghong Sun, Yunwei Lou, Thomas Porturas, Samantha Morrissey, George Luo, Ji Qi, Qingguo Ruan, Songlin Shi, and Youhai H. Chen, “Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice,” Journal Of Immunology, vol. 194, no. 12, pp. 5736–5742, 2015. View at Publisher · View at Google Scholar
  • A. Menconi, X. Hernandez-Velasco, E. A. Vicuna, V. A. Kuttappan, O. B. Faulkner, G. Tellez, B. M. Hargis, and L. R. Bielke, “Histopathological and morphometric changes induced by a dextran sodium sulfate (DSS) model in broilers,” Poultry Science, vol. 94, no. 5, pp. 906–911, 2015. View at Publisher · View at Google Scholar
  • Cambrian Y. Liu, Philip E. Dube, Nandini Girish, Ajay T. Reddy, and D. Brent Polk, “Optical reconstruction of murine colorectal mucosa at cellular resolution,” American Journal Of Physiology-Gastrointestinal And Liver Physiology, vol. 308, no. 9, pp. G721–G735, 2015. View at Publisher · View at Google Scholar
  • Xiaodong Ma, Fang Yan, Qipan Deng, Fenge Li, Zhongxin Lu, Mofang Liu, Lisheng Wang, Daniel J Conklin, James McCracken, Sanjay Srivastava, Aruni Bhatnagar, and Yong Li, “Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer,” Cell Discovery, vol. 1, pp. 15005, 2015. View at Publisher · View at Google Scholar
  • Nobumi Suzuki, Naoko Murata-Kamiya, Kohei Yanagiya, Wataru Suda, Masahira Hattori, Hiroaki Kanda, Atsuhiro Bingo, Yumiko Fujii, Shin Maeda, Kazuhiko Koike, and Masanori Hatakeyama, “Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein,” Scientific Reports, vol. 5, pp. 10024, 2015. View at Publisher · View at Google Scholar
  • Zachary T. Bitzer, Shannon L. Glisan, Melanie R. Dorenkott, Katheryn M. Goodrich, Liyun Ye, Sean F. O’Keefe, Joshua D. Lambert, and Andrew P. Neilson, “Cocoa Procyanidins with Different Degrees of Polymerization Possess Distinct Activities in Models of Colonic Inflammation,” The Journal of Nutritional Biochemistry, 2015. View at Publisher · View at Google Scholar
  • Md. Abul Hasnat, Mehnaz Pervin, Sa Ra Park, Yong Chang Jang, Ji Hong Lim, Young Jun Kim, Young Ock Kim, Hyung Jung Kweon, and Beong Ou Lim, “Anti-inflammatory, counteractive, and preventive effects of orally administrated oat extracts on dextran sulfate sodium-induced colitis in mice,” Food Science and Biotechnology, vol. 24, no. 2, pp. 619–628, 2015. View at Publisher · View at Google Scholar
  • Michael Bramhall, Oscar Flórez-Vargas, Robert Stevens, Andy Brass, and Sheena Cruickshank, “Quality of Methods Reporting in Animal Models of Colitis,” Inflammatory Bowel Diseases, pp. 1, 2015. View at Publisher · View at Google Scholar
  • Antara Banerjee, Debora Bizzaro, Patrizia Burra, Rosa Di Liddo, Surajit Pathak, Diletta Arcidiacono, Andrea Cappon, Patrizio Bo, Maria Teresa Conconi, Marika Crescenzi, Claudia Maria Assunta Pinna, Pier Paolo Parnigotto, Malcolm R Alison, Giacomo Carlo Sturniolo, Renata D’Incà, and Francesco Paolo Russo, “Umbilical cord mesenchymal stem cells modulate dextran sulphate sodium induced acute colitis in immunodeficient mice,” Stem Cell Research & Therapy, vol. 6, no. 1, 2015. View at Publisher · View at Google Scholar
  • V. A. Kuttappan, L. R. Berghman, E. A. Vicuna, J. D. Latorre, A. Menconi, J. D. Wolchok, A. D. Wolfenden, O. B. Faulkner, G. I. Tellez, B. M. Hargis, and L. R. Bielke, “Poultry enteric inflammation model with dextran sodium sulfate mediated chemical induction and feed restriction in broilers,” Poultry Science, 2015. View at Publisher · View at Google Scholar
  • Raghavan Chinnadurai, Spencer Ng, Vijayakumar Velu, and Jacques Galipeau, “Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease,” World Journal Of Gastroenterology, vol. 21, no. 16, pp. 4779–4787, 2015. View at Publisher · View at Google Scholar
  • Matthias Ernst, Adele Preaudet, and Tracy Putoczki, “Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice,” Jove-Journal Of Visualized Experiments, no. 97, 2015. View at Publisher · View at Google Scholar
  • Yi Shen, Jun Ma, Ruilan Yan, Hongyan Ling, Xiaoning Li, Wancai Yang, John Gao, Chenfei Huang, Yiwen Bu, Yu Cao, Yingchun He, Laxiang Wan, Xuyu Zu, Jianghua Liu, Mei Chris Huang, William F. Stenson, Duan-Fang Liao, and Deliang Cao, “Impaired Self-Renewal and Increased Colitis and Dysplastic Lesions in Colonic Mucosa of AKR1B8-Deficient Mice,” Clinical Cancer Research, vol. 21, no. 6, pp. 1466–1476, 2015. View at Publisher · View at Google Scholar
  • Alexandra Wittmann, Peter A. Bron, Iris I. van Swam, Michiel Kleerebezem, Patrick Adam, Kerstin Gronbach, Sarah Menz, Isabell Flade, Annika Bender, Andrea Schäfer, Ali Giray Korkmaz, Raphael Parusel, Ingo B. Autenrieth, and Julia-Stefanie Frick, “TLR Signaling-induced CD103-expressing Cells Protect Against Intestinal Inflammation,” Inflammatory Bowel Diseases, vol. 21, no. 3, pp. 507–519, 2015. View at Publisher · View at Google Scholar
  • Eiman A. Hasby, Marwa A. Hasby, Zeinab Shohieb, and Kholoud El Noby, “Foxp3+ T regulatory cells and Immunomodualation after Schistosoma Mansoni Egg Antigen Immunization in Experimental Model of Inflammatory Bowel Disease,” Cellular Immunology, 2015. View at Publisher · View at Google Scholar
  • K. Kishida, M. Kohyama, Y. Kurashima, Y. Kogure, J. Wang, K. Hirayasu, T. Suenaga, H. Kiyono, J. Kunisawa, and H. Arase, “Negative regulation of DSS-induced experimental colitis by PILR ,” International Immunology, 2015. View at Publisher · View at Google Scholar
  • Jaana Rautava, Lee J Pinnell, Linda Vong, Nadia Akseer, Amit Assa, and Philip M Sherman, “Oral microbiome composition changes in mouse models of colitis,” Journal of Gastroenterology and Hepatology, vol. 30, no. 3, pp. 521–527, 2015. View at Publisher · View at Google Scholar
  • Katarzyna Oficjalska, Mathilde Raverdeau, Gabriella Aviello, Siobhan C. Wade, Ana Hickey, Katherine M. Sheehan, Sinead C. Corr, Elaine W. Kay, Luke A. O'Neill, Kingston H. G. Mills, and Emma M. Creagh, “Protective Role for Caspase-11 during Acute Experimental Murine Colitis,” Journal Of Immunology, vol. 194, no. 3, pp. 1252–1260, 2015. View at Publisher · View at Google Scholar
  • Germaine D. Agollah, Grace Wu, Ho-Lan Peng, and Sunkuk Kwon, “Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice,” World Journal Of Gastroenterology, vol. 21, no. 45, pp. 12767–12777, 2015. View at Publisher · View at Google Scholar
  • Matthew R. Panasevich, Jacob M. Allen, Matthew A. Wallig, Jeffrey A. Woods, and Ryan N. Dilger, “Moderately Fermentable Potato Fiber Attenuates Signs and Inflammation Associated with Experimental Colitis in Mice,” Journal Of Nutrition, vol. 145, no. 12, pp. 2781–2788, 2015. View at Publisher · View at Google Scholar
  • Yo Han Park, Nayoung Kim, Young Kwang Shim, Yoon Jin Choi, Ryoung Hee Nam, Yoon Jeong Choi, Min Hee Ham, Ji Hyung Suh, Sun Min Lee, Chang Min Lee, Hyuk Yoon, Hye Seung Lee, and Dong Ho Lee, “Adequate Dextran Sodium Sulfate-induced Colitis Model in Mice and Effective Outcome Measurement Method,” Journal of Cancer Prevention, vol. 20, no. 4, pp. 260–267, 2015. View at Publisher · View at Google Scholar
  • Younggeon Jin, Tiffany A. Pridgen, and Anthony T. Blikslager, “Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis,” Inflammatory Bowel Diseases, vol. 21, no. 12, pp. 2747–2757, 2015. View at Publisher · View at Google Scholar
  • Stefanie Gross, Dina Balderes, Jing Liu, Samuel Asfaha, Guoqiang Gu, Timothy C. Wang, and Lori Sussel, “Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential,” American Journal Of Physiology-Gastrointestinal And Liver Physiology, vol. 309, no. 12, pp. G975–G987, 2015. View at Publisher · View at Google Scholar
  • Di Zhao, Antao Xu, Zhanghan Dai, Jiangchen Peng, Mingming Zhu, Jun Shen, Qing Zheng, and Zhihua Ran, “WNT5A transforms intestinal CD8αα+ IELs into an unconventional phenotype with pro-inflammatory features,” BMC Gastroenterology, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Masaaki Kawano, Rie Takagi, Atsushi Kaneko, and Sho Matsushita, “Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses,” Journal of Neuroimmunology, vol. 289, pp. 43–55, 2015. View at Publisher · View at Google Scholar
  • David Padua, John P. Vu, Patrizia M. Germano, and Joseph R. Pisegna, “The Role of Neuropeptides in Mouse Models of Colitis,” Journal of Molecular Neuroscience, 2015. View at Publisher · View at Google Scholar
  • Motohiro Nonaka, “Function of the glycosyltransferase GnT-V in colitis,” Journal of Gastroenterology, 2015. View at Publisher · View at Google Scholar
  • Katja M. Bendtsen, Line Fisker, Axel K. Hansen, Camilla H.F. Hansen, and Dennis S. Nielsen, “The influence of the young microbiome on inflammatory diseases-Lessons from animal studies,” Birth Defects Research Part C: Embryo Today: Reviews, 2015. View at Publisher · View at Google Scholar
  • Luciano P. Pedrotti, Bibiana E. Barrios, Lisa Maccio-Maretto, Allisson F. Bento, Angela A. Sena, María Cecilia Rodriguez-Galán, João B. Calixto, and Silvia G. Correa, “ Systemic IL-12 burst expands intestinal T-lymphocyte subsets bearing the α 4 β 7 integrin in mice ,” European Journal of Immunology, 2015. View at Publisher · View at Google Scholar
  • Marina Rosengarten, Nurit Hadad, Yulia Solomonov, Sergio Lamprecht, and Rachel Levy, “ Cytosolic phospholipase A 2 α has a crucial role in the pathogenesis of DSS-induced colitis in mice ,” European Journal of Immunology, vol. 46, no. 2, pp. 400–408, 2015. View at Publisher · View at Google Scholar
  • Suguru Shigemori, Takafumi Watanabe, Kai Kudoh, Masaki Ihara, Shireen Nigar, Yoshinari Yamamoto, Yoshihito Suda, Takashi Sato, Haruki Kitazawa, and Takeshi Shimosato, “Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice,” Microbial Cell Factories, vol. 14, no. 1, 2015. View at Publisher · View at Google Scholar
  • Janelle A. Jiminez, Trina C. Uwiera, G. Douglas Inglis, and Richard R. E. Uwiera, “Animal models to study acute and chronic intestinal inflammation in mammals,” Gut Pathogens, vol. 7, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jana Prochazkova, Shinya Sakaguchi, Michel Owusu, Abdelghani Mazouzi, Marc Wiedner, Georgia Velimezi, Martin Moder, Gleb Turchinovich, Anastasiya Hladik, Elisabeth Gurnhofer, Adrian Hayday, Axel Behrens, Sylvia Knapp, Lukas Kenner, Wilfried Ellmeier, and Joanna I. Loizou, “DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation,” Plos Genetics, vol. 11, no. 11, 2015. View at Publisher · View at Google Scholar
  • Vishal Khatri, Nitin Amdare, Aaditya Tarnekar, Kalyan Goswami, and Maryada Venkata Rami Reddy, “ Brugia malayi cystatin therapeutically ameliorates dextran sulfate sodium-induced colitis in mice ,” Journal of Digestive Diseases, vol. 16, no. 10, pp. 585–594, 2015. View at Publisher · View at Google Scholar
  • Bosi Yuan, Shuping Zhou, Youke Lu, Jiong Liu, Xinxin Jin, Haijun Wan, and Fangyu Wang, “Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis,” Gut and Liver, vol. 9, no. 6, pp. 734, 2015. View at Publisher · View at Google Scholar
  • Sumika Tokieda, Marie Komori, Toshifumi Ishiguro, Yoichiro Iwakura, Kazuhiko Takahara, and Kayo Inaba, “Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis,” BMC Immunology, vol. 16, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jichun Chen, Mark A. Bryant, James J. Dent, Yu Sun, Marie J. Desierto, and Neal S. Young, “Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion,” Experimental Gerontology, 2015. View at Publisher · View at Google Scholar
  • Wenjie Guo, Shasha Hu, Ahmed Elgehama, Fenli Shao, Ren Ren, Wen Liu, Wenjing Zhang, Xinlei Wang, Renxiang Tan, Qiang Xu, Yang Sun, and Ruihua Jiao, “Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition,” Journal Of Pharmacological Sciences, vol. 129, no. 2, pp. 101–106, 2015. View at Publisher · View at Google Scholar
  • M. Nakanishi, C. Perret, E. J. Meuillet, and D. W. Rosenberg, “Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis,” Carcinogenesis, 2015. View at Publisher · View at Google Scholar
  • Dana Ben-Ami Shor, Tomer Bashi, Jordan Lachnish, Mati Fridkin, Giorgia Bizzaro, Iris Barshak, Miri Blank, and Yehuda Shoenfeld, “Phosphorylcholine-tuftsin compound prevents development of dextransulfate-sodium-salt induced murine colitis: Implications for the treatment of human ,” Journal Of Autoimmunity, vol. 56, pp. 111–117, 2015. View at Publisher · View at Google Scholar
  • Karl Blirando, Elodie Mintet, Valérie Buard, Jean-Christophe Sabourin, Marc Benderitter, Fabien Milliat, and Agnès François, “Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice,” Digestive Diseases and Sciences, 2015. View at Publisher · View at Google Scholar
  • Jessica I. Grill, Jens Neumann, Felix Hiltwein, Frank T. Kolligs, and Marlon R. Schneider, “Intestinal E-cadherin Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis,” Digestive Diseases and Sciences, 2015. View at Publisher · View at Google Scholar
  • Louise M. Judd, Heather V. Chalinor, Anna Walduck, Daniel I. Pavlic, Jan Daebritz, Zinaida Dubeykovskaya, Timothy C. Wang, Trevelyan R. Menheniott, and Andrew S. Giraud, “TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marr,” American Journal Of Physiology-Gastrointestinal And Liver Physiology, vol. 308, no. 1, pp. G12–G24, 2015. View at Publisher · View at Google Scholar
  • Elisabeth Lippert, Manuela Stieber-Gunckel, Nadja Dunger, Werner Falk, Florian Obermeier, and Claudia Kunst, “Galectin-3 Modulates Experimental Colitis,” Digestion, vol. 92, no. 1, pp. 45–53, 2015. View at Publisher · View at Google Scholar
  • Junfeng Zhu, Fangli Yang, Lixuan Sang, Jingbo Zhai, Xiaoqing Zhang, Dan Yue, Shengjun Li, Yan Li, Changlong Lu, and Xun Sun, “IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses,” Mediators of Inflammation, vol. 2015, pp. 1–12, 2015. View at Publisher · View at Google Scholar
  • Sung-Ho Shin, Jia-Le Song, Myoung-Gyu Park, Mi-Hyun Park, Sung-Joo Hwang, and Kun-Young Park, “Effects of natural raw meal (NRM) on high-fat diet and dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice,” Nutrition Research and Practice, vol. 9, no. 6, pp. 619, 2015. View at Publisher · View at Google Scholar
  • Andrea Buda, Sonia Facchin, Elisa Dassie, Elisabetta Casarin, Mark A. Jepson, Helmut Neumann, Giorgia Hatem, Stefano Realdon, Renata D'Inca, Giacomo Carlo Sturniolo, and Margherita Morpurgo, “Detection of a fluorescent-labeled avidin-nucleic acid nanoassembly by confocal laser endomicroscopy in the microvasculature of chronically inflamed i,” International Journal Of Nanomedicine, vol. 10, pp. 399–408, 2015. View at Publisher · View at Google Scholar
  • Derek A. Martin, and Bradley W. Bolling, “A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases,” Food Funct., vol. 6, no. 6, pp. 1773–1786, 2015. View at Publisher · View at Google Scholar
  • So-young Lee, Hwain Kim, Kyoungmi Kim, Hyunji Lee, Seungbok Lee, and Daekee Lee, “Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon,” Scientific Reports, vol. 6, pp. 26923, 2016. View at Publisher · View at Google Scholar
  • V. A. Kuttappan, E. A. Vicuña, O. B. Faulkner, G. R. Huff, K. A. Freeman, J. D. Latorre, A. Menconi, G. I. Tellez, B. M. Hargis, and L. R. Bielke, “Evaluation of changes in serum chemistry in association with feed withdrawal or high dose oral gavage with dextran sodium sulfate- (DSS-) induced gut leakage in broiler chickens,” Poultry Science, pp. pew171, 2016. View at Publisher · View at Google Scholar
  • Hyun Jung Lee, Sun-Hee Oh, Hui Won Jang, Ji-Hee Kwon, Kyoung Jin Lee, Chung Hee Kim, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, and Won Ho Kim, “Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis,” Gut and Liver, vol. 10, no. 3, 2016. View at Publisher · View at Google Scholar
  • E. Liana Falcone, Loreto Abusleme, Muthulekha Swamydas, Michail S. Lionakis, Li Ding, Amy P. Hsu, Adrian M. Zelazny, Niki M. Moutsopoulos, Douglas B. Kuhns, Clay Deming, Mariam Quiñones, Julia A. Segre, Clare E. Bryant, and Steven M. Holland, “Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome,” Microbiome, vol. 4, no. 1, 2016. View at Publisher · View at Google Scholar
  • Yue Guo, Yue Liu, Chengyue Zhang, Zheng-Yuan Su, Wenji Li, Mou-Tuan Huang, and Ah-Ng Kong, “The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice,” Carcinogenesis, pp. bgw042, 2016. View at Publisher · View at Google Scholar
  • Wing-Yan Wong, Magnolia Muk-Lan Lee, Brandon Dow Chan, Richard Kin-Tin Kam, Ge Zhang, Ai-Ping Lu, and William Chi-Shing Tai, “Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages,” Proteomics, vol. 16, no. 7, pp. 1131–1145, 2016. View at Publisher · View at Google Scholar
  • Lauren Van Der Kraak, David Langlais, Serge Jothy, Nicole Beauchemin, and Philippe Gros, “Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice,” Mammalian Genome, 2016. View at Publisher · View at Google Scholar
  • Xiaoping Wang, Yang Sun, Yue Zhao, Youxiang Ding, Xiaobo Zhang, Lingyi Kong, Zhiyu Li, Qinglong Guo, and Li Zhao, “Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation,” Biochemical Pharmacology, 2016. View at Publisher · View at Google Scholar
  • M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J. S Brunner, H Paar, K Soukup, A Halfmann, A. M. Dohnal, C. W. Steiner, S. Blüml, J. Basilio, B. Hochreiter, M. Salzmann, B. Hoesel, G. Lametschwandtner, R. Eferl, J. A. Schmid, and G. Schabbauer, “Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition,” OncoImmunology, pp. 00–00, 2016. View at Publisher · View at Google Scholar
  • Yan-hong Li, Hai-tao Xiao, Dong-dong Hu, Sarwat Fatima, Cheng-yuan Lin, Huai-xue Mu, Nikki P. Lee, and Zhao-xiang Bian, “Berberine Ameliorates Chronic Relapsing Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice by Suppressing Th17 Responses,” Pharmacological Research, 2016. View at Publisher · View at Google Scholar
  • Nicholas Edward Ilott, Julia Bollrath, Camille Danne, Chris Schiering, Matthew Shale, Krista Adelmann, Thomas Krausgruber, Andreas Heger, David Sims, and Fiona Powrie, “Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling,” The ISME Journal, 2016. View at Publisher · View at Google Scholar
  • Shujie Liu, Yongming Li, Bo Deng, and Ziwei Xu, “Recombinant Lactococcus lactis expressing porcine insulin-like growth factor I ameliorates DSS-induced colitis in mice,” BMC Biotechnology, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Jacques R. Nicoli, Samir D. Elian, Laís M. Paula, Éricka L. Souza, Angélica T. Vieira, Cristiana C. Garcia, Mauro M. Teixeira, Rosa M. Arantes, and Flaviano S. Martins, “Escherichia coli strain Nissle 1917 ameliorates experimental colitis by modulating intestinal permeability, the inflammatory response and clinical signs in a faecal transplantation model,” Journal of Medical Microbiology, vol. 65, no. 3, pp. 201–210, 2016. View at Publisher · View at Google Scholar
  • Zhiqi Chen, Kai Yu, Fang Zhu, and Reginald Gorczynski, “Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced Colitis,” Plos One, vol. 11, no. 2, 2016. View at Publisher · View at Google Scholar
  • M Gómez-Suárez, I Z Gutiérrez-Martínez, J A Hernández-Trejo, M Hernández-Ruiz, D Suárez-Pérez, A Candelario, R Kamekura, O Medina-Contreras, M Schnoor, V Ortiz-Navarrete, N Villegas-Sepúlveda, C Parkos, A Nusrat, and P Nava, “14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells,” Cell Death and Differentiation, 2016. View at Publisher · View at Google Scholar
  • Zhihui Tian, Jie Liu, Mengyu Liao, Wenjuan Li, Jiaqi Zou, Xinxin Han, Mingjie Kuang, Wanqiu Shen, and Haidong Li, “Beneficial Effects of Fecal Microbiota Transplantation on Ulcerative Colitis in Mice,” Digestive Diseases and Sciences, 2016. View at Publisher · View at Google Scholar
  • Yazmín K. Márquez-Flores, Isabel Villegas, Ana Cárdeno, M. Ángeles Rosillo, and Catalina Alarcón-de-la-Lastra, “Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways,” The Journal of Nutritional Biochemistry, 2016. View at Publisher · View at Google Scholar
  • Bojana Simovic Markovic, Aleksandar Nikolic, Marina Gazdic, Sanja Bojic, Ljubica Vucicevic, Milica Kosic, Slobodanka Mitrovic, Milos Milosavljevic, Gurdyal Besra, Vladimir Trajkovic, Nebojsa Arsenijevic, Miodrag L. Lukic, and Vladislav Volarevic, “Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages,” Journal of Crohn's and Colitis, pp. jjw013, 2016. View at Publisher · View at Google Scholar
  • Hilda Vargas Robles, Alí Francisco Citalán Madrid, Alexander García Ponce, Angelica Silva Olivares, Mineko Shibayama, Abigail Betanzos, Leonardo Del Valle Mondragón, Porfirio Nava, and Michael Schnoor, “Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Jong-Chan Jang, Kang Min Lee, and Seong-Gyu Ko, “ Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis ,” Mediators of Inflammation, vol. 2016, pp. 1–13, 2016. View at Publisher · View at Google Scholar