Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Table 1

Susceptibility to DSS-induced colitis among inbred strains (adapted from [15]).

	Cecum	Proximal colon	Middle colon	Distal colon
DBA/2J	BC	—	A	A
NON/LtJ	AB	—	A	A
NON.H2^g7	AB	—	AB	AB
129/SvPas	A	—	AB	B
NOD-scid	D	A	AB	BC
C57BL/6J	BC	A	B	BC
C3H/HeJ	D	A	AB	C
NOD/LtJ	CD	—	B	BC
C3H/HeJBir	D	A	AB	C

Strains that do not share the same letter in a column have significat differences in histological score for particular part of the colon after DSS administration. Letter A denotes the lowest histological score, while D denotes the highest histological score observed among the strains. — denotes no changes found in the colon (normal mucosa).