Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Table 2

Differentially expressed genes in acute phase of DSS colitis that had been previously associated with human IBD [34].

Gene	Name	Expression	Gene      Name	Expression
Cytokine			Genes involved in tissue remodeling
IL-6	Interleukine-6	↑ 2.6	Mmp3       Stromelysin 1	↑ 22.5
IL-16	Interleukine-16	↓ 2.7	Mmp14    Membrane type 1 MMP	↑ 2.1
IL-22	Interleukine-22	↑ 2.4	Timp1     Tissue inhibitor of metalloproteinase 1	↑ 3.6
Chemokine			Regenerating islet-derived genes
CCL2	JE (human:MCP-1)	↑ 1.8	Reg3γ     Regenerating islet-derived 3γ	↑ 14.0
CCL3	MIP-1α	↑ 3.3	Pap      Pancreatitis-associated protein	↑ 79.1
CCL11	Eotaxin	↑ 3.3	S-100a9    S-100 calcium-binding protein A9 (calgranulin B)	↑ 14.0
CXCL1	KC (hu: GROα)	↑ 2.9	Prostaglandin metabolism
CXCL5	LIX (hu: ENA-78)	↑ 6.6	Ptgs2     Prostaglandin-endoperoxidase synthase 2 (COX-2)	↑ 4.1

Colitis was induced in 8 wk female BALB/c mice that received 3% DSS for 7 days and were sacrificed on day 7. ↑: significantly increased expression by denoted factor, ↓: significantly decreased expression by denoted factor.