Table 2: Differentially expressed genes in acute phase of DSS colitis that had been previously associated with human IBD [34].

GeneNameExpressionGene      Name Expression

CytokineGenes involved in tissue remodeling
 IL-6Interleukine-6↑ 2.6 Mmp3       Stromelysin 1 ↑ 22.5
 IL-16Interleukine-16 2.7 Mmp14    Membrane type 1 MMP ↑ 2.1
 IL-22Interleukine-22↑ 2.4 Timp1    Tissue inhibitor of metalloproteinase 1 ↑ 3.6

Chemokine Regenerating islet-derived genes
 CCL2JE (human:MCP-1)↑ 1.8 Reg3γ    Regenerating islet-derived 3γ ↑ 14.0
 CCL3MIP-1α↑ 3.3 Pap     Pancreatitis-associated protein ↑ 79.1
 CCL11Eotaxin↑ 3.3 S-100a9    S-100 calcium-binding protein A9 (calgranulin B) ↑ 14.0
 CXCL1KC (hu: GROα)↑ 2.9Prostaglandin metabolism
 CXCL5LIX (hu: ENA-78)↑ 6.6 Ptgs2     Prostaglandin-endoperoxidase synthase 2 (COX-2) ↑ 4.1

Colitis was induced in 8 wk female BALB/c mice that received 3% DSS for 7 days and were sacrificed on day 7. ↑: significantly increased expression by denoted factor, : significantly decreased expression by denoted factor.