- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 721285, 8 pages
Sesquiterpene Lactones Isolated from Elephantopus scaber L. Inhibits Human Lymphocyte Proliferation and the Growth of Tumour Cell Lines and Induces Apoptosis In Vitro
1Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India
2Organic Chemistry Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Thiruvananthapuram 695 019, India
3Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India
4Cancer Research Division, Regional Cancer Centre, Thiruvananthapuram 695 011, India
Received 19 July 2011; Revised 28 October 2011; Accepted 29 October 2011
Academic Editor: Ikhlas A. Khan
Copyright © 2012 B. S. Geetha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- B. S. Geetha, S. Shymal, P. Remani, P. G. Latha, and S. Rajasekharan, “Plant products as anticancer agents,” in Recent Progress in Medicinal Plants, J. N. Govil, et al., Ed., vol. 16, pp. 323–338, Studium Press, 2007.
- H. Ichikawa, M. S. Nair, Y. Takada et al., “Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression,” Clinical Cancer Research, vol. 12, no. 19, pp. 5910–5918, 2006.
- G. Xu, Q. Liang, Z. Gong, W. Yu, S. He, and L. Xi, “Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L,” Experimental Oncology, vol. 28, no. 2, pp. 106–109, 2006.
- T. K. Tabopda, J. Ngoupayo, J. Liu et al., “Further cytotoxic sesquiterpene lactones from Elephantopus mollis Kunth,” Chemical and Pharmaceutical Bulletin, vol. 56, no. 2, pp. 231–233, 2008.
- E. Rodriguez, G. H. N. Towers, and J. C. Mitchell, “Biological activities of sesquiterpene lactones,” Phytochemistry, vol. 15, no. 11, pp. 1573–1580, 1976.
- B. S. Geetha, Antitumour and Immunomodulatory Properties of Elephantopus scaber L., Ph.D. thesis, University of Kerala, India, 2004.
- J. B. Harborne, Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis, Chapman & Hall, London, UK, 2nd edition, 1984.
- T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983.
- J. F. R. Kerr, C. M. Winterford, and B. V. Harmon, “Apoptosis: its significance in cancer and cancer therapy,” Cancer, vol. 73, no. 8, pp. 2013–2026, 1994.
- B. S. Geetha, P. G. Latha, P. Remani, and S. Rajasekharan, “Antitumor effect of Elephantopus scaber Linn,” Journal of Tropical Medicinal Plants, vol. 4, pp. 75–79, 2002.
- T. R. Govindachari, N. Viswanathan, and H. Führer, “Isodeoxyelephantopin, a new germacranolide from Elephantopus scaber Linn,” Indian Journal of Chemistry, vol. 10, pp. 272–273, 1972.
- P. P. H. But, P. M. Hon, H. Cao et al., “Sesquiterpene lactones from Elephantopus scaber,” Phytochemistry, vol. 44, no. 1, pp. 113–116, 1997.
- S. M. Kupchan, M. A. Eakin, and A. M. Thomas, “Tumor inhibitors. 69. Structure-cytotoxicity relationships among the sesquiterpene lactones,” Journal of Medicinal Chemistry, vol. 14, no. 12, pp. 1147–1152, 1971.
- H. J. Woerdenbag, I. Merfort, C. M. Passreiter et al., “Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines,” Planta Medica, vol. 60, no. 5, pp. 434–437, 1994.
- J. Meenakshi and G. Shanmugam, “Cleistanthin A, a diphyllin glycoside from Cleistanthus collinus, is cytotoxic to PHA-stimulated (proliferating) human lymphocytes,” Drug Development Research, vol. 51, no. 3, pp. 187–190, 2000.
- T. C. Hsieh, D. Halicka, X. Lu et al., “Effects of resveratrol on the G0-G1 transition and cell cycle progression of mitogenically stimulated human lymphocytes,” Biochemical and Biophysical Research Communications, vol. 297, no. 5, pp. 1311–1317, 2002.
- O. Spring, J. Kupka, B. Maier, and A. Hager, “Biological activities of sesquiterpene lactones from Helianthus annuus: antimicrobial and cytotoxic properties; influence on DNA, RNA, and protein synthesis,” Zeitschrift fur Naturforschung C, vol. 37, no. 11-12, pp. 1087–1091, 1982.
- V. M. Dirsch, H. Stuppner, and A. M. Vollmar, “Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis,” Planta Medica, vol. 67, no. 6, pp. 557–559, 2001.
- C. P. Da Silva, C. R. De Oliveira, and M. D. C. P. De Lima, “Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes,” Biochemical Pharmacology, vol. 51, no. 10, pp. 1331–1340, 1996.