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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 721285, 8 pages
http://dx.doi.org/10.1155/2012/721285
Research Article

Sesquiterpene Lactones Isolated from Elephantopus scaber L. Inhibits Human Lymphocyte Proliferation and the Growth of Tumour Cell Lines and Induces Apoptosis In Vitro

1Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India
2Organic Chemistry Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Thiruvananthapuram 695 019, India
3Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram 695 562, India
4Cancer Research Division, Regional Cancer Centre, Thiruvananthapuram 695 011, India

Received 19 July 2011; Revised 28 October 2011; Accepted 29 October 2011

Academic Editor: Ikhlas A. Khan

Copyright © 2012 B. S. Geetha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. S. Geetha, S. Shymal, P. Remani, P. G. Latha, and S. Rajasekharan, “Plant products as anticancer agents,” in Recent Progress in Medicinal Plants, J. N. Govil, et al., Ed., vol. 16, pp. 323–338, Studium Press, 2007.
  2. H. Ichikawa, M. S. Nair, Y. Takada et al., “Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression,” Clinical Cancer Research, vol. 12, no. 19, pp. 5910–5918, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Xu, Q. Liang, Z. Gong, W. Yu, S. He, and L. Xi, “Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L,” Experimental Oncology, vol. 28, no. 2, pp. 106–109, 2006. View at Scopus
  4. T. K. Tabopda, J. Ngoupayo, J. Liu et al., “Further cytotoxic sesquiterpene lactones from Elephantopus mollis Kunth,” Chemical and Pharmaceutical Bulletin, vol. 56, no. 2, pp. 231–233, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Rodriguez, G. H. N. Towers, and J. C. Mitchell, “Biological activities of sesquiterpene lactones,” Phytochemistry, vol. 15, no. 11, pp. 1573–1580, 1976. View at Scopus
  6. B. S. Geetha, Antitumour and Immunomodulatory Properties of Elephantopus scaber L., Ph.D. thesis, University of Kerala, India, 2004.
  7. J. B. Harborne, Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis, Chapman & Hall, London, UK, 2nd edition, 1984.
  8. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Scopus
  9. J. F. R. Kerr, C. M. Winterford, and B. V. Harmon, “Apoptosis: its significance in cancer and cancer therapy,” Cancer, vol. 73, no. 8, pp. 2013–2026, 1994. View at Scopus
  10. B. S. Geetha, P. G. Latha, P. Remani, and S. Rajasekharan, “Antitumor effect of Elephantopus scaber Linn,” Journal of Tropical Medicinal Plants, vol. 4, pp. 75–79, 2002.
  11. T. R. Govindachari, N. Viswanathan, and H. Führer, “Isodeoxyelephantopin, a new germacranolide from Elephantopus scaber Linn,” Indian Journal of Chemistry, vol. 10, pp. 272–273, 1972.
  12. P. P. H. But, P. M. Hon, H. Cao et al., “Sesquiterpene lactones from Elephantopus scaber,” Phytochemistry, vol. 44, no. 1, pp. 113–116, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. S. M. Kupchan, M. A. Eakin, and A. M. Thomas, “Tumor inhibitors. 69. Structure-cytotoxicity relationships among the sesquiterpene lactones,” Journal of Medicinal Chemistry, vol. 14, no. 12, pp. 1147–1152, 1971. View at Scopus
  14. H. J. Woerdenbag, I. Merfort, C. M. Passreiter et al., “Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines,” Planta Medica, vol. 60, no. 5, pp. 434–437, 1994. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Meenakshi and G. Shanmugam, “Cleistanthin A, a diphyllin glycoside from Cleistanthus collinus, is cytotoxic to PHA-stimulated (proliferating) human lymphocytes,” Drug Development Research, vol. 51, no. 3, pp. 187–190, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. T. C. Hsieh, D. Halicka, X. Lu et al., “Effects of resveratrol on the G0-G1 transition and cell cycle progression of mitogenically stimulated human lymphocytes,” Biochemical and Biophysical Research Communications, vol. 297, no. 5, pp. 1311–1317, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Spring, J. Kupka, B. Maier, and A. Hager, “Biological activities of sesquiterpene lactones from Helianthus annuus: antimicrobial and cytotoxic properties; influence on DNA, RNA, and protein synthesis,” Zeitschrift fur Naturforschung C, vol. 37, no. 11-12, pp. 1087–1091, 1982. View at Scopus
  18. V. M. Dirsch, H. Stuppner, and A. M. Vollmar, “Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis,” Planta Medica, vol. 67, no. 6, pp. 557–559, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. C. P. Da Silva, C. R. De Oliveira, and M. D. C. P. De Lima, “Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes,” Biochemical Pharmacology, vol. 51, no. 10, pp. 1331–1340, 1996. View at Publisher · View at Google Scholar · View at Scopus