Sesquiterpene Lactones Isolated from Elephantopus scaber L. Inhibits Human Lymphocyte Proliferation and the Growth of Tumour Cell Lines and Induces Apoptosis In Vitro

Table 3

Effect of intraperitoneal administration of deoxyelephantopin on the life span of DLA-tumour-bearing mice.

Treatments	Number of mice survived after tumour inoculation (days)			Mean survival time (days)	Life span (%)	Increase in life span (%)
	15	25	35
Group I DLA (Control)	10/10	5/10	0/10	22.56±2.57	100	—
Group II DLA + Deoxy-elephantopin (25 mg/kg, i.p)	10/10	6/10	3/10	30.90±3.36	136.96	36.96
Group III DLA + Deoxy-elephantopin (50 mg/kg, i.p)	10/10	8/10	5/10	37.82±3.70	167.64	67.64
Group IV DLA + Deoxy-elephantopin (100 mg/kg, i.p)	10/10	8/10	6/10	38.92±3.5^∗∗∗	172.51	72.51
Group V DLA + Vincristine (1 mg/kg, i.p)	10/10	10/10	6/10	43.54±3.9	192.99	92.99

Values are mean ± SD of three experiments, 𝑛=10, ***𝑃<0.001 compared to control (the time period required for the death of all the animals in the control group was 22).