The Plasminogen Activation System and the Regulation of Catecholaminergic Function

Figure 1

Corelease of t-PA with norepinephrine from catecholaminergic cells. PC12 cells (a) or bovine adrenal chromaffin cells (b) were labeled with [³H]-norepinephrine and incubated at 37°C for 30 min in either the absence or presence of 60 μM nicotine, 55 mM KCl, or 2 mM BaCl₂. The release buffer was aspirated, cells were harvested and lysed, and the release of t-PA antigen (open bars) and [³H]-norepinephrine (filled bars) was determined. [7]. ©The American Society for Biochemistry and Molecular Biology.

(a)

(b)