Figure 4: Effect of cells on cleavage of 125I-CgA by plasmin. Either PC12 cells (filled bars) or buffer (open bars) was incubated with unlabeled plasminogen. Then, 125I-CgA and t-PA were added in either the presence or the absence of EACA. The reactions were stopped by addition of aprotinin and centrifuged. The supernatants were analyzed for % TCA precipitability. Results are as mean + SEM; for each experimental group. ** compared to each of the experimental groups. .