Figure 1: Alterations of plasma 17β-E2 and Hcy levels after 12 wk different treatment. (a) Plasma 17β-E2 levels. Ovariectomy induced a significant decrease of plasma 17β-E2; supplementation with genistein for 12 wk had no significant effect on it. (b) Plasma Hcy levels. 2.5% Met diet for 12 wk induced a significant increase in plasma Hcy levels, and ovariectomy could further enhance the increase of Hcy. Genistein supplementation could significantly lower the elevated Hcy levels. The results are shown as mean ± SEM (), all values were obtained by one-way ANOVA analysis. versus Con; OVX + Met versus Met; versus OVX + Met.