Characterization of Flavonol Inhibition of DnaB Helicase: Real-Time Monitoring, Structural Modeling, and Proposed Mechanism
Figure 9
(a) The binding pose of KpDnaB to Myr is different from that of Que. Que interacts with L214 and N215, whereas Myr interacts with L214, N247, and F460. (b) Myr was docked in different positions of the ATP-binding pocket of both DNA-unbound and DNA-bound models of KpDnaB. Myr interacts with L214, N247, and F460 in the DNA-unbound model, and interacts with L214 and N462 in the DNA-bound model of KpDnaB, respectively.
