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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 735989, 10 pages
http://dx.doi.org/10.1155/2012/735989
Research Article

Animal Experimental Study of the Fully Biodegradable Atrial Septal Defect (ASD) Occluder

Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Received 14 June 2012; Revised 7 August 2012; Accepted 7 August 2012

Academic Editor: George E. Plopper

Copyright © 2012 Yu-feng Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was conducted to evaluate the feasibility, safety, biocompatibility, and degradation features of a fully biodegradable occluder for closure of atrial septal defect (ASD) in an acute canine model. The ASD was created in 20 healthy mongrel dogs by the brockenbrough needle, and the fully biodegradable occluders were implanted by self-made delivery system. The success rate and complications were observed. Acute ASD models were successfully created in 18 dogs, and 16 occluders were successfully implanted in the ASD models. Animals were sacrificed at different times after procedure. The cardiac gross anatomy showed that all occluders were stable in the interatrial septum, no vegetation or thrombus formation was observed on the surface of all occluders. They were embedded into endogenous host tissue gradually at 12-week follow-up. Different periods of pathological observations suggested that the occluders degraded gradually over about 24 weeks and essentially became an integral part of the septum. Transcatheter closure of ASD in acute canine model using the fully biodegradable ASD occluder has the potential of a high successful rate of technique, excellent biocompatibility, and fewer complications with adequate, immediate, and short-term results.