Animal Experimental Study of the Fully Biodegradable Atrial Septal Defect (ASD) Occluder
Figure 4
Gross inspection of the occluder at different time points after procedure (white arrows show the biodegradable occluder, and black arrows for the tricuspid annulus). (a) 2 weeks after procedure, the occluder shape was kept, the surface of occluder was covered with a layer of newborn film, PDO wire was clearly visible; (b) 4 weeks after procedure, the surface of occluder was covered with a certain amount of connective tissue, the occluder shape was kept, and partially fusion with the endocardial, PDO wire was still clearly visible; (c) 8 weeks after procedure, the surface of occluder was covered with reddish-white film, the PDO wire was still visible; (d) 12 weeks after procedure, the surface of the occluder was basically covered with milky-white film, mixed with a little red, the PDO wire was faintly visible; (e) 24 weeks after procedure, the surface of the occluder was covered with a dense porcelain-white film, the PDO wire has been unidentifiable; (f) 24 weeks after procedure, the occluder was bisected by a symmetrical cut, the occluder has become an integral part of the septum, the contour was still visible, but the PDO wire and PLA film have been unable to identify.
