Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular

Figure 1

Schematic diagram displaying the functional domains of PEDF. (1) Phosphorylation zones—induce different degrees of antiangiogenic and neurotrophic activity, (2) 34-mer peptide region which has antiangiogenic, blocks cell migration, and induces tumour cell apoptotic activity, (3) 44-mer peptide region which has neurotrophic and cell differentiation activity, (4) basic region (positive) which is necessary for heparin binding, and (5) acidic region (negative) which is responsible for collagen binding and lacks neurotrophic activity.