- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 758169, 7 pages
MicroRNAs and Induced Pluripotent Stem Cells for Human Disease Mouse Modeling
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB C512, Newark, NJ 07103, USA
Received 10 December 2011; Accepted 14 February 2012
Academic Editor: Monica Fedele
Copyright © 2012 Chingiz Underbayev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- N. L. Washington, M. A. Haendel, C. J. Mungall, M. Ashburner, M. Westerfield, and S. E. Lewis, “Linking human diseases to animal models using ontology-based phenotype annotation,” PLoS Biology, vol. 7, no. 11, Article ID e1000247, 2009.
- M. A. Bedell, N. A. Jenkins, and N. G. Copeland, “Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice,” Genes and Development, vol. 11, no. 1, pp. 1–10, 1997.
- L. Hook, C. O'Brien, and T. Allsopp, “ES cell technology: an introduction to genetic manipulation, differentiation and therapeutic cloning,” Advanced Drug Delivery Reviews, vol. 57, no. 13, pp. 1904–1917, 2005.
- H. Niwa, “Mouse ES cell culture system as a model of development,” Development Growth and Differentiation, vol. 52, no. 3, pp. 275–283, 2010.
- S. Ohtsuka and S. Dalton, “Molecular and biological properties of pluripotent embryonic stem cells,” Gene Therapy, vol. 15, no. 2, pp. 74–81, 2008.
- A. Bradley, M. Evans, M. H. Kaufman, and E. Robertson, “Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines,” Nature, vol. 309, no. 5965, pp. 255–256, 1984.
- E. Robertson, A. Bradley, M. Kuehn, and M. Evans, “Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector,” Nature, vol. 323, no. 6087, pp. 445–448, 1986.
- K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006.
- K. Okita, M. Nakagawa, H. Hyenjong, T. Ichisaka, and S. Yamanaka, “Generation of mouse induced pluripotent stem cells without viral vectors,” Science, vol. 322, no. 5903, pp. 949–953, 2008.
- M. Stadtfeld, M. Nagaya, J. Utikal, G. Weir, and K. Hochedlinger, “Induced pluripotent stem cells generated without viral integration,” Science, vol. 322, no. 5903, pp. 945–949, 2008.
- T. Seki, S. Yuasa, M. Oda et al., “Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells,” Cell stem cell, vol. 7, no. 1, pp. 11–14, 2010.
- M. Wernig, A. Meissner, R. Foreman et al., “In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state,” Nature, vol. 448, no. 7151, pp. 318–324, 2007.
- J. Zou, M. L. Maeder, P. Mali et al., “Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells,” Cell Stem Cell, vol. 5, no. 1, pp. 97–110, 2009.
- M. I. Lai, W. Y. Wendy-Yeo, R. Ramasamy et al., “Advancements in reprogramming strategies for the generation of induced pluripotent stem cells,” Journal of Assisted Reproduction and Genetics, vol. 28, no. 4, pp. 291–301, 2011.
- K. Takahashi, “Direct reprogramming 101,” Development Growth and Differentiation, vol. 52, no. 3, pp. 319–333, 2010.
- X. Y. Zhao, W. Li, Z. Lv et al., “IPS cells produce viable mice through tetraploid complementation,” Nature, vol. 461, no. 7260, pp. 86–90, 2009.
- E. Salerno, B. J. Scaglione, F. D. Coffman et al., “Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity,” Molecular Cancer Therapeutics, vol. 8, no. 9, pp. 2684–2692, 2009.
- Y. Yao, B. Nashun, T. Zhou et al., “Generation of CD34+ cells from CCR5-disrupted human embryonic and induced pluripotent stem cells,” Human Gene Therapy, vol. 23, no. 2, pp. 238–242, 2012.
- E. X. Lee, D. H. Lam, C. Wu et al., “Glioma gene therapy using induced pluripotent stem cell derived neural stem cells,” Molecular Pharmaceutics, vol. 8, no. 5, pp. 1515–1524, 2011.
- J. Hanna, M. Wernig, S. Markoulaki et al., “Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin,” Science, vol. 318, no. 5858, pp. 1920–1923, 2007.
- J. T. Dimos, K. T. Rodolfa, K. K. Niakan et al., “Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons,” Science, vol. 321, no. 5893, pp. 1218–1221, 2008.
- A. D. Ebert, J. Yu, F. F. Rose et al., “Induced pluripotent stem cells from a spinal muscular atrophy patient,” Nature, vol. 457, no. 7227, pp. 277–280, 2009.
- I. H. Park, N. Arora, H. Huo et al., “Disease-specific induced pluripotent stem cells,” Cell, vol. 134, no. 5, pp. 877–886, 2008.
- F. Soldner, D. Hockemeyer, C. Beard et al., “Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors,” Cell, vol. 136, no. 5, pp. 964–977, 2009.
- L. Ye, J. C. Chang, C. Lin, X. Sun, J. Yu, and Y. W. Kan, “Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 24, pp. 9826–9830, 2009.
- M. Wernig, J. P. Zhao, J. Pruszak et al., “Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 15, pp. 5856–5861, 2008.
- Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D. A. Melton, “In vivo reprogramming of adult pancreatic exocrine cells to β-cells,” Nature, vol. 455, no. 7213, pp. 627–632, 2008.
- I. S. Behbahan, Y. Duan, A. Lam et al., “New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes,” Stem Cell Reviews and Reports, vol. 7, no. 3, pp. 748–759, 2011.
- S. Asgari, M. Moslem, K. Bagheri-Lankarani, B. Pournasr, M. Miryounesi, and H. Baharvand, “Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells,” Stem Cell Reviews and Reports. In press.
- S. K. Mallanna and A. Rizzino, “Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells,” Developmental Biology, vol. 344, no. 1, pp. 16–25, 2010.
- T. M. Rana, “Illuminating the silence: understanding the structure and function of small RNAs,” Nature Reviews Molecular Cell Biology, vol. 8, no. 1, pp. 23–36, 2007.
- C. Melton, R. L. Judson, and R. Blelloch, “Opposing microRNA families regulate self-renewal in mouse embryonic stem cells,” Nature, vol. 463, no. 7281, pp. 621–626, 2010.
- Y. Tay, J. Zhang, A. M. Thomson, B. Lim, and I. Rigoutsos, “MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation,” Nature, vol. 455, no. 7216, pp. 1124–1128, 2008.
- Y. M. S. Tay, W. L. Tam, Y. S. Ang et al., “MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1,” Stem Cells, vol. 26, no. 1, pp. 17–29, 2008.
- Y. Lee, C. Ahn, J. Han et al., “The nuclear RNase III Drosha initiates microRNA processing,” Nature, vol. 425, no. 6956, pp. 415–419, 2003.
- Y. Lee, K. Jeon, J. T. Lee, S. Kim, and V. N. Kim, “MicroRNA maturation: stepwise processing and subcellular localization,” EMBO Journal, vol. 21, no. 17, pp. 4663–4670, 2002.
- Y. Zeng and B. R. Cullen, “Sequence requirements for micro RNA processing and function in human cells,” RNA, vol. 9, no. 1, pp. 112–123, 2003.
- V. K. Gangaraju and H. Lin, “MicroRNAs: key regulators of stem cells,” Nature Reviews Molecular Cell Biology, vol. 10, no. 2, pp. 116–125, 2009.
- A. Marson, S. S. Levine, M. F. Cole et al., “Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells,” Cell, vol. 134, no. 3, pp. 521–533, 2008.
- K. D. Wilson, S. Venkatasubrahmanyam, F. Jia, N. Sun, A. J. Butte, and J. C. Wu, “MicroRNA profiling of human-induced pluripotent stem cells,” Stem Cells and Development, vol. 18, no. 5, pp. 749–757, 2009.
- Y. Wang, R. Medvid, C. Melton, R. Jaenisch, and R. Blelloch, “DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal,” Nature Genetics, vol. 39, no. 3, pp. 380–385, 2007.
- N. Xu, T. Papagiannakopoulos, G. Pan, J. A. Thomson, and K. S. Kosik, “MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells,” Cell, vol. 137, no. 4, pp. 647–658, 2009.
- C. S. Yang, Z. Li, and T. M. Rana, “microRNAs modulate iPS cell generation,” RNA, vol. 17, no. 8, pp. 1451–1460, 2011.
- K. N. Ivey, A. Muth, J. Arnold et al., “MicroRNA regulation of cell lineages in mouse and human embryonic stem cells,” Cell Stem Cell, vol. 2, no. 3, pp. 219–229, 2008.
- Y. Zhao, E. Samal, and D. Srivastava, “Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis,” Nature, vol. 436, no. 7048, pp. 214–220, 2005.
- F. Anokye-Danso, C. M. Trivedi, D. Juhr et al., “Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency,” Cell Stem Cell, vol. 8, no. 4, pp. 376–388, 2011.
- J. Ren, P. Jin, E. Wang, F. M. Marincola, and D. F. Stroncek, “MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells,” Journal of Translational Medicine, vol. 7, article 20, 2009.
- L. R. Saunders, et al., “miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues,” Aging, vol. 2, no. 7, pp. 415–431, 2010.
- C. C. Lan, I. U. S. Leong, D. Lai, and D. R. Love, “Disease modeling by gene targeting using MicroRNAs,” Methods in Cell Biology, vol. 105, pp. 419–436, 2011.
- L. Krenacs, A. W. Himmelmann, L. Quintanilla-Martinez et al., “Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas,” Blood, vol. 92, no. 4, pp. 1308–1316, 1998.
- E. Y. Chung, M. Dews, D. Cozma et al., “c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster,” Cancer Biology and Therapy, vol. 7, no. 11, pp. 1758–1764, 2008.
- P. H. Gunaratne, “Embryonic stem cell MicroRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?” Current Stem Cell Research and Therapy, vol. 4, no. 3, pp. 168–177, 2009.