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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 759503, 5 pages
http://dx.doi.org/10.1155/2012/759503
Review Article

Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation

1Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung, Taiwan
3Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan
4Department of Pediatrics, Taoyuan General Hospital, Taoyuan, Taiwan
5Bionet Corporation, Taipei, Taiwan
6Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
7School of Chinese Medicine, China Medical University, Taichung, Taiwan
8Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Received 18 July 2012; Accepted 31 July 2012

Academic Editor: Somayeh Shahrokhi

Copyright © 2012 Yu-Hua Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hematopoietic stem cell transplantation (HSCT) is becoming an effective therapeutic modality for a variety of diseases. Mesenchymal stem cells (MSCs) can be used to enhance hematopoietic engraftment, accelerate lymphocyte recovery, reduce the risk of graft failure, prevent and treat graft-versus-host disease, and repair tissue damage in patients receiving HSCT. Till now, most MSCs for human clinical application have been derived from bone marrow. However, acquiring bone-marrow-derived MSCs involves an invasive procedure. Umbilical cord is rich with MSCs. Compared to bone-marrow-derived MSCs, umbilical cord-derived MSCs (UCMSCs) are easier to obtain without harm to the donor and can proliferate faster. No severe adverse effects were noted in our previous clinical application of UCMSCs in HSCT. Accordingly, application of UCMSCs in humans appears to be feasible and safe. Further studies are warranted.