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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 759503, 5 pages
http://dx.doi.org/10.1155/2012/759503
Review Article

Umbilical Cord-Derived Mesenchymal Stem Cells for Hematopoietic Stem Cell Transplantation

1Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung, Taiwan
3Department of Pediatrics, Buddhist Tzu-Chi General Hospital, Taichung Branch, Taichung, Taiwan
4Department of Pediatrics, Taoyuan General Hospital, Taoyuan, Taiwan
5Bionet Corporation, Taipei, Taiwan
6Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
7School of Chinese Medicine, China Medical University, Taichung, Taiwan
8Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

Received 18 July 2012; Accepted 31 July 2012

Academic Editor: Somayeh Shahrokhi

Copyright © 2012 Yu-Hua Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Friedenstein, I. I. Piatetzky-Shapiro, and K. V. Petrakova, “Osteogenesis in transplants of bone marrow cells,” Journal of Embryology and Experimental Morphology, vol. 16, no. 3, pp. 381–390, 1966. View at Scopus
  2. B. H. Su, K. H. Wu, H. Y. Lin, M. H. Lin, C. T. Peng, and C. Tsai, “Umbilical cord-derived mesenchymal stem cells for severe bronchpulmonary dysplasia,” Pediatrics, vol. 126, no. 125, pp. 1127–1133, 2011.
  3. K. H. Wu, C. K. Chan, C. Tsai et al., “Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells,” Transplantation, vol. 91, no. 12, pp. 1412–1416, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. H. Chao, C. Tsai, C. T. Peng et al., “Cotransplantation of umbilical cord MSCs to enhance engraftment of hematopoietic stem cells in patients with severe aplastic anemia,” Bone Marrow Transplantation, vol. 46, no. 10, pp. 1391–1392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Dominici, K. Le Blanc, I. Mueller et al., “Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement,” Cytotherapy, vol. 8, no. 4, pp. 315–317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. Y. Zhang, S. H. Teoh, M. S. K. Chong et al., “Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells,” Stem Cells, vol. 27, no. 1, pp. 126–137, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. J. Minguell, A. Erices, and P. Conget, “Mesenchymal stem cells,” Experimental Biology and Medicine, vol. 226, no. 6, pp. 507–520, 2001. View at Scopus
  8. G. Lazennec and C. Jorgensen, “Concise review: adult multipotent stromal cells and cancer: risk or benefit?” Stem Cells, vol. 26, no. 6, pp. 1387–1394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. R. J. Deans and A. B. Moseley, “Mesenchymal stem cells: biology and potential clinical uses,” Experimental Hematology, vol. 28, no. 8, pp. 875–884, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Ito, H. Hasauda, T. Kitajima, and T. Kiyono, “Ex vivo expansion of human cord blood hematopoietic progenitor cells using glutaraldehyde-fixed human bone marrow stromal cells,” Journal of Bioscience & Bioengineering, vol. 102, no. 5, pp. 467–469, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. C. L. da Silva, R. Gonçalves, K. B. Crapnell, J. M. S. Cabral, E. D. Zanjani, and G. Almeida-Porada, “A human stromal-based serum-free culture system supports the ex vivo expansion/maintenance of bone marrow and cord blood hematopoietic stem/progenitor cells,” Experimental Hematology, vol. 33, no. 7, pp. 828–835, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Li, P. Feugier, B. Serrurrier et al., “Human mesenchymal stem cells improve ex vivo expansion of adult human CD34+ peripheral blood progenitor cells and decrease their allostimulatory capacity,” Experimental Hematology, vol. 35, no. 3, pp. 507–515, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Almeida-Porada, A. W. Flake, H. A. Glimp, and E. D. Zanjani, “Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero,” Experimental Hematology, vol. 27, no. 10, pp. 1569–1575, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Almeida-Porada, C. D. Porada, N. Tran, and E. D. Zanjani, “Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation,” Blood, vol. 95, no. 11, pp. 3620–3627, 2000. View at Scopus
  15. W. A. Noort, A. B. Kruisselbrink, P. S. In't Anker et al., “Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34+ cells in NOD/SCID mice,” Experimental Hematology, vol. 30, no. 8, pp. 870–878, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Friedman, M. Betancur, L. Boissel, H. Tuncer, C. Cetrulo, and H. Klingemann, “Umbilical cord mesenchymal stem cells: adjuvants for human cell transplantation,” Biology of Blood and Marrow Transplantation, vol. 13, no. 12, pp. 1477–1486, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. D. L. Troyer and M. L. Weiss, “Concise review: Wharton's Jelly-derived cells are a primitive stromal cell population,” Stem Cells, vol. 26, no. 3, pp. 591–599, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Pelagiadis, H. Dimitriou, and M. Kalmanti, “Biologic characteristics of mesenchymal stromal cells and their clinical applications in pediatric patients,” Journal of Pediatric Hematology/Oncology, vol. 30, no. 4, pp. 301–309, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. B. J. Jones and S. J. McTaggart, “Immunosuppression by mesenchymal stromal cells: from culture to clinic,” Experimental Hematology, vol. 36, no. 6, pp. 733–741, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Aggarwal and M. F. Pittenger, “Human mesenchymal stem cells modulate allogeneic immune cell responses,” Blood, vol. 105, no. 4, pp. 1815–1822, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Bartholomew, C. Sturgeon, M. Siatskas et al., “Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo,” Experimental Hematology, vol. 30, no. 1, pp. 42–48, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Prevosto, M. Zancolli, P. Canevali, M. R. Zocchi, and A. Poggi, “Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction,” Haematologica, vol. 92, no. 7, pp. 881–888, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Corcione, F. Benvenuto, E. Ferretti et al., “Human mesenchymal stem cells modulate B-cell functions,” Blood, vol. 107, no. 1, pp. 367–372, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Ramasamy, H. Fazekasova, E. W. F. Lam, I. Soeiro, G. Lombardi, and F. Dazzi, “Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle,” Transplantation, vol. 83, no. 1, pp. 71–76, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Rasmusson, O. Ringdén, B. Sundberg, and K. Le Blanc, “Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells,” Transplantation, vol. 76, no. 8, pp. 1208–1213, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Di Nicola, C. Carlo-Stella, M. Magni et al., “Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli,” Blood, vol. 99, no. 10, pp. 3838–3843, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Glennie, I. Soeiro, P. J. Dyson, E. W. F. Lam, and F. Dazzi, “Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells,” Blood, vol. 105, no. 7, pp. 2821–2827, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Campagnoli, I. A. Roberts, S. Kumar, P. R. Bennett, I. Bellantuono, and N. M. Fisk, “Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow,” Blood, vol. 98, no. 8, pp. 2396–2402, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. P. V. Guillot, C. Gotherstrom, J. Chan, H. Kurata, and N. M. Fisk, “Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC,” Stem Cells, vol. 25, no. 3, pp. 646–654, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. P. S. In 't Anker, W. A. Noort, S. A. Scherjon et al., “Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential,” Haematologica, vol. 88, no. 8, pp. 845–852, 2003. View at Scopus
  31. S. A. Wexler, C. Donaldson, P. Denning-Kendall, C. Rice, B. Bradley, and J. M. Hows, “Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not,” British Journal of Haematology, vol. 121, no. 2, pp. 368–374, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Kern, H. Eichler, J. Stoeve, H. Klüter, and K. Bieback, “Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue,” Stem Cells, vol. 24, no. 5, pp. 1294–1301, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Yu, Z. Xiao, L. Shen, and L. Li, “Mid-trimester fetal blood-derived adherent cells share characteristics similar to mesenchymal stem cells but full-term umbilical cord blood does not,” British Journal of Haematology, vol. 124, no. 5, pp. 666–675, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Secco, E. Zucconi, N. M. Vieira et al., “Multipotent stem cells from umbilical cord: cord is richer than blood!,” Stem Cells, vol. 26, no. 1, pp. 146–150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. S. Tsai, S. M. Hwang, K. D. Chen et al., “Functional network analysis of the transcriptomes of mesenchymal stem cells derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow,” Stem Cells, vol. 25, no. 10, pp. 2511–2523, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Götherström, A. West, J. Liden, M. Uzunel, R. Lahesmaa, and K. Le Blanc, “Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells,” Haematologica, vol. 90, no. 8, pp. 1017–1026, 2005. View at Scopus
  37. W. Wagner, F. Wein, A. Seckinger et al., “Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood,” Experimental Hematology, vol. 33, no. 11, pp. 1402–1416, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Stenderup, J. Justesen, C. Clausen, and M. Kassem, “Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,” Bone, vol. 33, no. 6, pp. 919–926, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Baksh, R. Yao, and R. S. Tuan, “Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow,” Stem Cells, vol. 25, no. 6, pp. 1384–1392, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. L. L. Lu, Y. J. Liu, S. G. Yang et al., “Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials,” Haematologica, vol. 91, no. 8, pp. 1017–1026, 2006. View at Scopus
  41. Y. J. Chang, D. T. Shih, C. P. Tseng, T. B. Hsieh, D. C. Lee, and S. M. Hwang, “Disparate mesenchyme-lineage tendencies in mesenchymal stem cells from human bone marrow and umbilical cord blood,” Stem Cells, vol. 24, no. 3, pp. 679–685, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. O. N. Koç, S. L. Gerson, B. W. Cooper et al., “Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy,” Journal of Clinical Oncology, vol. 18, no. 2, pp. 307–316, 2000. View at Scopus
  43. H. M. Lazarus, O. N. Koc, S. M. Devine et al., “Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients,” Biology of Blood and Marrow Transplantation, vol. 11, no. 5, pp. 389–398, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Bacigalupo, M. Valle, M. Podestà et al., “T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia,” Experimental Hematology, vol. 33, no. 7, pp. 819–827, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. H. Chao, C. T. Peng, H. J. Harn, C. K. Chan, and K. H. Wu, “Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia,” Annals of Hematology, vol. 89, no. 7, pp. 715–723, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Le Blanc, H. Samuelsson, B. Gustafsson et al., “Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells,” Leukemia, vol. 21, no. 8, pp. 1733–1738, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. L. M. Ball, M. E. Bernardo, H. Roelofs et al., “Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation,” Blood, vol. 110, no. 7, pp. 2764–2767, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Le Blanc, I. Rasmusson, B. Sundberg et al., “Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells,” The Lancet, vol. 363, no. 9419, pp. 1439–1441, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. O. Ringdén, M. Uzunel, I. Rasmusson et al., “Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease,” Transplantation, vol. 81, no. 10, pp. 1390–1397, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. E. M. Villaron, J. Almeida, N. López-Holgado et al., “Mesenchymal stem cells are present in peripheral blood and can engraft after allogeneic hematopoietic stem cell transplantation,” Haematologica, vol. 89, no. 12, pp. 1421–1427, 2004. View at Scopus
  51. A. Poloni, P. Leoni, L. Buscemi et al., “Engraftment capacity of mesenchymal cells following hematopoietic stem cell transplantation in patients receiving reduced-intensity conditioning regimen,” Leukemia, vol. 20, no. 2, pp. 329–335, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. N. Awaya, K. Rupert, E. Bryant, and B. Torok-Storb, “Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation,” Experimental Hematology, vol. 30, no. 8, pp. 937–942, 2002. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Banfi, A. Muraglia, B. Dozin, M. Mastrogiacomo, R. Cancedda, and R. Quarto, “Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy,” Experimental Hematology, vol. 28, no. 6, pp. 707–715, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Sundin, C. Örvell, I. Rasmusson, B. Sundberg, O. Ringdén, and K. Le Blanc, “Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual,” Bone Marrow Transplantation, vol. 37, no. 11, pp. 1051–1059, 2006. View at Publisher · View at Google Scholar · View at Scopus