Research Article
Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas
Table 1
MPG expression in human glioma and nonneoplastic brain tissues with different clinical-pathological features.
| Clinicopathological features |
No. of cases | MPG (n, %) | P | − | + | ++ | +++ |
| Human glioma tissues | | | | | | | WHO grade | | | | | | | I | 18 | 14 (77.8) | 4 (22.2) | 0 | 0 | 0.002 | II | 14 | 8 (57.1) | 4 (28.6) | 2 (14.3) | 0 | III | 38 | 4 (10.5) | 19 (50.0) | 13 (34.2) | 2 (5.3) | IV | 58 | 0 | 0 | 15 (25.9) | 43(74.1) | Age | | | | | | | <55 | 52 | 7 (13.5) | 11 (21.2) | 14 (26.9) | 20 (38.5) | NS | ≥55 | 76 | 19 (25.0) | 16 (21.1) | 16 (21.1) | 25 (32.9) | Gender | | | | | | | Male | 76 | 19 (25.0) | 19 (25.0) | 15 (19.7) | 23 (30.2) | NS | Female | 52 | 7 (13.5) | 8 (15.4) | 15 (28.8) | 22 (42.3) | KPS | | | | | | | <80 | 78 | 6 (7.7) | 15 (19.2) | 22 (28.2) | 35 (44.9) | 0.01 | ≥80 | 50 | 20 (40.0) | 12 (24.0) | 8 (16.0) | 10 (20.0) | Surgery | | | | | | | Gross total resection | 98 | 18 (18.4) | 19 (19.4) | 28 (28.6) | 33 (33.7) | NS | Partial resection | 24 | 6 (25.0) | 6 (25.0) | 1 (4.2) | 11 (45.8) | Biopsy | 6 | 2 (33.3) | 2 (33.3) | 1 (16.7) | 1 (16.7) | Nonneoplastic brain tissues | | | | | | | Age | | | | | | | <55 | 4 | 3 (75.0) | 1 (25.0) | 0 | 0 | NS | ≥55 | 6 | 5 (83.3) | 1 (16.7) | 0 | 0 | Gender | | | | | | | Male | 6 | 5 (83.3) | 1 (16.7) | 0 | 0 | NS | Female | 4 | 3 (75.0) | 1 (25.0) | 0 | 0 |
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