Research Article

Attenuating Effect of Ginkgo biloba Leaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

Table 1

Plasma ALT, AST, GGT, ALP, total protein, albumin, glucose, triglycerides, cholesterol, HDL-L, and LDL-C levels (mean ± SD) of control, TAA, TTA plus G. biloba leaves extract, and G. biloba leaves extract treated mice ( 𝑛 = 7). Percentage changes are included in parentheses.

ParametersTreatments
Control TAATAA + leaves extract Leaves extract

ALT (U/L) 2 6 . 6 3 ± 2 . 0 6 5 8 . 0 0 ± 1 2 . 1 5 ab33.63 ± 6.35ac 2 4 . 7 5 ± 3 . 0 1
(+117.8)(+26.9) ( 7 . 1 )
AST (U/L) 4 1 . 3 8 ± 5 . 1 0 8 3 . 5 0 ± 2 3 . 4 0 ab49.87 ± 11.64 4 1 . 0 0 ± 5 . 9 3
(+101.8)(+20.5) ( 0 . 9 )
GGT (U/L) 4 . 7 9 ± 0 . 5 5 1 1 . 5 5 ± 1 . 3 1 ab5.83 ± 1.33c 4 . 5 4 ± 0 . 4 8
(+141.1)(+21.7) ( 5 . 2 )
ALP (U/L) 1 1 8 . 5 6 ± 8 . 7 0 1 8 2 . 6 3 ± 2 5 . 2 8 ab127.38 ± 17.78 1 1 9 . 1 3 ± 8 . 8 6
(+54.0)(+7.4) ( + 0 . 5 )
Total protein (g/dL) 5 . 6 7 ± 0 . 2 9 4 . 6 3 ± 0 . 3 0 ab5.36 ± 0.67 5 . 6 3 ± 0 . 2 3
(−18.3) ( 5 . 5 ) ( 0 . 7 )
Albumin (g/dL) 3 . 6 9 ± 0 . 3 1 2 . 8 7 ± 0 . 3 6 ab3.30 ± 0.55 3 . 7 1 ± 0 . 2 9
(−22.2) ( 1 0 . 6 ) ( + 0 . 5 )
Glucose (mg/dL) 8 5 . 4 3 ± 6 . 9 0 6 9 . 5 7 ± 8 . 0 6 ab76.14 ± 6.87c 8 6 . 0 0 ± 6 . 0 9
( 1 8 . 6 ) ( 1 0 . 9 ) ( + 0 . 7 )
Triglycerides (mg/dL) 7 0 . 0 0 ± 4 . 4 4 136.14 ± 16.38ab99.14 ± 17.7ac 7 0 . 8 5 ± 5 . 3 4
(+94.5)(+41.6) ( + 1 . 2 )
Cholesterol (mg/dL) 9 2 . 4 3 ± 6 . 1 6 1 7 6 . 2 9 ± 3 5 . 6 8 ab139.29 ± 29.23ac 9 4 . 0 0 ± 9 . 9 3
(+90.7)(+50.7) ( + 1 . 7 )
HDL-C (mg/dL) 4 0 . 7 5 ± 2 . 2 7 3 2 . 0 0 ± 3 . 0 6 ab38.14 ± 2.0a 3 9 . 8 6 ± 2 . 8 0
(−21.5) ( 6 . 4 ) ( 2 . 2 )
LDL-C (mg/dL) 2 4 . 8 6 ± 2 . 2 8 4 6 . 1 4 ± 7 . 2 0 ab33.57 ± 3.82ac 2 2 . 7 5 ± 2 . 1 2
(+85.6)(+35.0)(−8.5)

aIndicates a significant difference between control and treated groups.
bIndicates a significant difference between the group treated with TAA and groups treated with TAA plus G. biloba leaves extract and G. biloba leaves extract.
cIndicates a significant difference between the group treated with TAA plus G. biloba leaves extract and group treated with G. biloba leaves extract.