About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 767369, 8 pages
http://dx.doi.org/10.1155/2012/767369
Research Article

Intrabone Transplant of Cord Blood Stem Cells Establishes a Local Engraftment Store: A Functional PET/FDG Study

1CNR Institute of Bioimages and Molecular Physiology, Section of Genoa, Via De Marini 6, 16149 Genoa, Italy
2Istituto Giannina Gaslini, Largo Gerolamo Gaslini, 16148 Genoa, Italy
3Department of Nuclear Medicine, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy
4Department of Hematology and Bone Marrow Transplantation, San Martino Hospital, Largo R. Benzi, 16132 Genoa, Italy
5Department of Mathematics, University of Genoa, Via Dodecaneso 35, 16146 Genoa, Italy
6Advanced Biotechnology Center, Largo R. Benzi 10, 16132 Genoa, Italy

Received 8 May 2012; Accepted 31 May 2012

Academic Editor: Somayeh Shahrokhi

Copyright © 2012 Cecilia Marini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. E. Wagner, N. A. Kernan, M. Steinbuch, H. E. Broxmeyer, and E. Gluckman, “Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease,” The Lancet, vol. 346, no. 8969, pp. 214–219, 1995. View at Scopus
  2. J. Kurtzberg, M. Laughlin, M. L. Graham et al., “Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients,” The New England Journal of Medicine, vol. 335, no. 3, pp. 157–166, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Wagner, J. Rosenthal, R. Sweetman et al., “Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft- versus-host disease,” Blood, vol. 88, no. 3, pp. 795–802, 1996. View at Scopus
  4. E. Gluckman and V. Rocha, “Cord blood transplantation:state of the art,” Haematologica, vol. 94, no. 4, pp. 451–454, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Gluckman, V. Rocha, A. Boyer-Chammard et al., “Outcome of cord-blood transplantation from related and unrelated donors,” The New England Journal of Medicine, vol. 337, no. 6, pp. 373–381, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. M. J. Laughlin, J. Barker, B. Bambach et al., “Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors,” The New England Journal of Medicine, vol. 344, no. 24, pp. 1815–1822, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. V. Rocha, M. Labopin, G. Sanz et al., “Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia,” The New England Journal of Medicine, vol. 351, no. 22, pp. 2276–2285, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. J. E. Wagner, J. N. Barker, T. E. DeFor et al., “Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival,” Blood, vol. 100, no. 5, pp. 1611–1618, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Rocha, J. Cornish, E. L. Sievers et al., “Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia,” Blood, vol. 97, no. 10, pp. 2962–2971, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Hägglund, O. Ringdén, B. Ågren et al., “Intraosseous compared to intravenous infusion of allogeneic bone marrow,” Bone Marrow Transplantation, vol. 21, no. 4, pp. 331–335, 1998. View at Scopus
  11. F. Frassoni, M. Podestà, R. Maccario et al., “Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation,” Blood, vol. 102, no. 3, pp. 1138–1141, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Castello, M. Podestà, V. G. Menditto et al., “Intra-bone marrow injection of bone marrow and cord blood cells: an alternative way of transplantation associated with a higher seeding efficiency,” Experimental Hematology, vol. 32, no. 8, pp. 782–787, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Frassoni, F. Gualandi, M. Podestà et al., “Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia: a phase I/II study,” The Lancet Oncology, vol. 9, no. 9, pp. 831–839, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Frassoni, R. Varaldo, F. Gualandi et al., “The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases,” Best Practice and Research, vol. 23, no. 2, pp. 237–244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Massollo, M. Podestà, C. Marini et al., “Contact with the bone marrow microenvironment readdresses the fate of transplanted hematopoietic stem cells,” Experimental Hematology, vol. 38, no. 10, pp. 968–977, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. J. C. M. Van der Loo and R. E. Ploemacher, “Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors,” Blood, vol. 85, no. 9, pp. 2598–2606, 1995. View at Scopus
  17. P. B. Van Hennik, A. E. De Koning, and R. E. Ploemacher, “Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: implications for stem cell frequency assessment,” Blood, vol. 94, no. 9, pp. 3055–3061, 1999. View at Scopus
  18. P. Rubinstein, L. Dobrila, R. E. Rosenfield et al., “Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 22, pp. 10119–10122, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. E. A. Kidd and P. W. Grigsby, “Intratumoral metabolic heterogeneity of cervical cancer,” Clinical Cancer Research, vol. 14, no. 16, pp. 5236–5241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Glucksberg, R. Storb, and A. Fefer, “Clinical manifestations of graft versus host disease in human recipients of marrow from HLA matched sibling donors,” Transplantation, vol. 18, no. 4, pp. 295–304, 1974. View at Scopus
  21. P. G. Camici, “Positron emission tomography and myocardial imaging,” Heart, vol. 83, no. 4, pp. 475–480, 2000. View at Scopus
  22. A. Agool, A. W. J. M. Glaudemans, H. H. Boersma, R. A. J. O. Dierckx, E. Vellenga, and R. H. J. A. Slart, “Radionuclide imaging of bone marrow disorders,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 38, no. 1, pp. 166–178, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Agool, B. W. Schot, P. L. Jager, and E. Vellenga, “18F-FLT PET in hematologic disorders: a novel technique to analyze the bone marrow compartment,” Journal of Nuclear Medicine, vol. 47, no. 10, pp. 1592–1598, 2006. View at Scopus
  24. S. Basu, M. Houseni, G. Bural et al., “Magnetic resonance imaging based bone marrow segmentation for quantitative calculation of pure red marrow metabolism using 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography: a novel application with significant implications for combined structure-function approach,” Molecular Imaging and Biology, vol. 9, no. 6, pp. 361–365, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Ramírez, C. G. Brunstein, B. Miller, T. Defor, and D. Weisdorf, “Delayed platelet recovery after allogeneic transplantation: a predictor of increased treatment-related mortality and poorer survival,” Bone Marrow Transplantation, vol. 46, no. 7, pp. 981–986, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Tricot, S. Jagannath, D. Vesole et al., “Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients,” Blood, vol. 85, no. 2, pp. 588–596, 1995. View at Scopus
  27. J. Jansen, S. G. Hanks, L. P. Akard et al., “Slow platelet recovery after PBPC transplantation from unrelated donors,” Bone Marrow Transplantation, vol. 43, no. 6, pp. 499–505, 2009. View at Publisher · View at Google Scholar · View at Scopus