Molecular Modeling of the M3 Acetylcholine Muscarinic Receptor and Its Binding Site

Figure 4

(a) Residues involved in the electrostatic lock between TM3 and TM6 helices in M3R. (b) Residues of M3R involved in hydrogen bonding with lipid oxygens. In bold are those residues have been also identified in a similar study in Rhodopsin (see text). W66^1.30, K94^1.58, K100^1.64, T127^2.63, Y167^3.51, R184^4.41, W252^6.33, R253^6.34, Y255^6.36, K256 ^6.37, S519^6.64, and K523^6.68.

(a)

(b)