Review Article
Role of Cytokines in Systemic Lupus Erythematosus: Recent Progress from GWAS and Sequencing
Table 1
Loci associated with SLE from GWAS. Table adapted from http://www.genome.gov/gwastudies/. A number of these genes were associated with SLE prior to GWAS and have now been replicated, while others await replication. Intergenic regions are listed in brackets. It is important to note that many genes associated with SLE in individuals of European ancestry are not associated with the disease in Asian populations, with the converse also holding true. Similar differences in susceptibility are certain to be found between other populations for whom the requisite GWAS have not yet been conducted. As Bustamante et al. [3] and others have pointed out, individuals of European ancestry are heavily overrepresented in GWAS, and many more comparison studies are needed to address this sampling bias.
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| 1Chung et al. [9] (NOTE: reported associations are for anti ds-DNA autoantibody production); 2Yang et al. [10]; 3 Yang et al. [11]; 4Han et al. [12]; 5Graham et al. [13]; 6Harley et al. [14]; 7Hom et al. [15]; 8Kozyrev et al. [16]; 9Gateva et al. [24]. A study by Li et al. (2011) did not report any significant associations. NOTE: The study by Gateva et al. [24] (9) was not genome wide, having used SNPs from 2,466 regions that showed nominal evidence of association to SLE (). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||