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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 806731, 7 pages
http://dx.doi.org/10.1155/2012/806731
Research Article

Effectiveness of Myocardial Contrast Echocardiography Quantitative Analysis during Adenosine Stress versus Visual Analysis before Percutaneous Therapy in Acute Coronary Pain: A Coronary Artery TIMI Grading Comparing Study

1Department of Image Center, Xuhui Central Hospital, Shanghai 200031, China
2Department of Echocardiography, Center of Medical Ultrasound, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830011, China
3Faculty of Medical Sciences, State University of Campinas (UNICAMP), 13083 Campinas, SP, Brazil
4Department of Radiology, The University of Chicago, Chicago, IL 60637, USA
5Instituto Israelita de Ensino e Pesquisa Albert Einstein, 05652 São Paulo, SP, Brazil

Received 29 February 2012; Revised 19 April 2012; Accepted 19 April 2012

Academic Editor: David J. Yang

Copyright © 2012 Lixia Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study aim was to compare two different stress echocardiography interpretation techniques based on the correlation with thrombosis in myocardial infarction (TIMI ) flow grading from acute coronary syndrome (ACS) patients. Forty-one patients with suspected ACS were studied before diagnostic coronary angiography with myocardial contrast echocardiography (MCE) at rest and at stress. The correlation of visual interpretation of MCE and TIMI flow grade was significant. The quantitative analysis (myocardial perfusion parameters: 𝐴 , 𝛽 , and 𝐴 × 𝛽 ) and TIMI flow grade were significant. MCE visual interpretation and TIMI flow grade had a high degree of agreement, on diagnosing myocardial perfusion abnormality. If one considers TIMI flow grade <3 as abnormal, MCE visual interpretation at rest had 73.1% accuracy with 58.2% sensitivity and 84.2% specificity and at stress had 80.4% accuracy with 76.6% sensitivity and 83.3% specificity. The MCE quantitative analysis has better accuracy with 100% of agreement with different level of TIMI flow grading. MCE quantitative analysis at stress has showed a direct correlation with TIMI flow grade, more significant than the visual interpretation technique. Further studies could measure the clinical relevance of this more objective approach to managing acute coronary syndrome patient before percutaneous coronary intervention (PCI).