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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 816159, 9 pages
http://dx.doi.org/10.1155/2012/816159
Research Article

Identification of Physiologically Active Substances as Novel Ligands for MRGPRD

1Exploratory Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo 134-8630, Japan
2Biologics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo 134-8630, Japan
3Oncology Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan
4Department of Chemical Biology, Gunma University Graduate School of Engineering, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan
5Institute for Biomolecular Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Tokyo 171-8588, Japan

Received 22 December 2011; Revised 6 April 2012; Accepted 5 May 2012

Academic Editor: S. L. Mowbray

Copyright © 2012 Makiko Uno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. A. F. Dixon, B. K. Kobilka, and D. J. Strader, “Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin,” Nature, vol. 321, no. 6065, pp. 75–79, 1986. View at Scopus
  2. B. K. Kobilka, C. MacGregor, K. Daniel, T. S. Kobilka, M. G. Caron, and R. J. Lefkowitz, “Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes,” Journal of Biological Chemistry, vol. 262, no. 32, pp. 15796–15802, 1987. View at Scopus
  3. C. C. Felder, E. M. Briley, J. Axelrod, J. T. Simpson, K. Mackie, and W. A. Devane, “Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 16, pp. 7656–7660, 1993. View at Scopus
  4. Y. Masu, K. Nakayama, H. Tamaki, Y. Harada, M. Kuno, and S. Nakanishi, “cDNA cloning of bovine substance-K receptor through oocyte expression system,” Nature, vol. 329, no. 6142, pp. 836–838, 1987. View at Scopus
  5. M. Parmentier, F. Libert, C. Maenhaut et al., “Molecular cloning of the thyrotropin receptor,” Science, vol. 246, no. 4937, pp. 1620–1622, 1989. View at Scopus
  6. X. Dong, S. K. Han, M. J. Zylka, M. I. Simon, and D. J. Anderson, “A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons,” Cell, vol. 106, no. 5, pp. 619–632, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. P. M. C. Lembo, E. Grazzini, T. Groblewski et al., “Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs,” Nature Neuroscience, vol. 5, no. 3, pp. 201–209, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Takeda, S. Kadowaki, T. Haga, H. Takaesu, and S. Mitaku, “Identification of G protein-coupled receptor genes from the human genome sequence,” FEBS Letters, vol. 520, no. 1-3, pp. 97–101, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Shinohara, M. Harada, K. Ogi et al., “Identification of a G protein-coupled receptor specifically responsive to β-alanine,” Journal of Biological Chemistry, vol. 279, no. 22, pp. 23559–23564, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Luo, S. R. Wickramasinghe, J. M. Savitt, J. W. Griffin, T. M. Dawson, and D. D. Ginty, “A hierarchical NGF signaling cascade controls ret-dependent and ret-independent events during development of nonpeptidergic DRG neurons,” Neuron, vol. 54, no. 5, pp. 739–754, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Zhang, N. Taylor, Y. Xie et al., “Cloning and expression of MRG receptors in macaque, mouse, and human,” Molecular Brain Research, vol. 133, no. 2, pp. 187–197, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. J. Zylka, F. L. Rice, and D. J. Anderson, “Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd,” Neuron, vol. 45, no. 1, pp. 17–25, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Fredriksson, M. C. Lagerström, L. G. Lundin, and H. B. Schiöth, “The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints,” Molecular Pharmacology, vol. 63, no. 6, pp. 1256–1272, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. S. K. Ajit, M. H. Pausch, J. D. Kennedy, and E. J. Kaftan, “Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 326020, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Seifert and K. Wenzel-Seifert, “Constitutive activity of G-proteins-coupled receptors: cause of disease and common property of wild-type receptors,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 366, no. 5, pp. 381–416, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Young, G. Waitches, and C. Birchmeier, “Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains,” Cell, vol. 45, no. 5, pp. 711–719, 1986. View at Scopus
  17. M. J. Pine, U. Kim, and C. Ip, “Free amino acid pools of rodent mammary tumors,” Journal of the National Cancer Institute, vol. 69, no. 3, pp. 729–735, 1982. View at Scopus
  18. M. Abe, M. Takahashi, and T. Nishidai, “The significance of urinary beta aminoisobutyric acid in cancer patients,” International Journal of Radiation Biology, vol. 24, no. 1, pp. 73–79, 1973. View at Scopus
  19. H. R. Nielsen, K. Nyholm, and K. E. Sjolin, “Beta-aminoisobutyric acid in urine from patients with bladder tumours,” Acta Pathologica et Microbiologica Scandinavica. Section A, vol. 78, no. 3, p. 368, 1970. View at Scopus
  20. T. P. Waalkes, C. W. Gehrke, and W. A. Bleyer, “Potential biologic markers in Burkitt's lymphoma,” Cancer Chemotherapy Reports, vol. 59, no. 4, pp. 721–727, 1975. View at Scopus
  21. T. P. Waalkes, C. W. Gehrke, and D. B. Lakings, “Beta aminoaciduria in patients with Burkitt's lymphoma,” Journal of the National Cancer Institute, vol. 57, no. 2, pp. 435–438, 1976. View at Scopus
  22. H. R. Nielsen and S. A. Killmann, “Urinary excretion of β-aminoisobutyrate and pseudouridine in acute and chronic myeloid leukemia,” Journal of the National Cancer Institute, vol. 71, no. 5, pp. 887–891, 1983. View at Scopus
  23. A. B. P. Van Kuilenburg, A. E. M. Stroomer, H. Van Lenthe, N. G. G. M. Abeling, and A. H. Van Gennip, “New insights in dihydropyrimidine dehydrogenase deficiency: A pivotal role for β-aminoisobutyric acid?” Biochemical Journal, vol. 379, no. 1, pp. 119–124, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. H. H. Tallan, S. Moore, and W. H. Stein, “Studies on the free amino acids and related compounds in the tissues of the cat,” The Journal of Biological Chemistry, vol. 211, no. 2, pp. 927–939, 1954. View at Scopus
  25. H. Fukazawa, S. Mizuno, and Y. Uehara, “A microplate assay for quantitation of anchorage-independent growth of transformed cells,” Analytical Biochemistry, vol. 228, no. 1, pp. 83–90, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. L. A. Kunz-Schughart, K. Groebe, and W. Mueller-Klieser, “Three-dimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation,” International Journal of Cancer, vol. 66, no. 4, pp. 578–586, 1996. View at Scopus
  27. D. J. Calvo and R. Miledi, “Activation of GABA(ρ1) receptors by glycine and β-alanine,” NeuroReport, vol. 6, no. 8, pp. 1118–1120, 1995. View at Scopus
  28. D. Choquet and H. Korn, “Does β-alanine activate more than one chloride channel associated receptor?” Neuroscience Letters, vol. 84, no. 3, pp. 329–334, 1988. View at Scopus
  29. T. Horikoshi, A. Asanuma, K. Yanagisawa, K. Anzai, and S. Goto, “Taurine and beta-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA,” Brain research, vol. 464, no. 2, pp. 97–105, 1988. View at Scopus
  30. M. Sandberg and I. Jacobson, “β-Alanine, a possible neurotransmitter in the visual system?” Journal of Neurochemistry, vol. 37, no. 5, pp. 1353–1356, 1981. View at Scopus
  31. V. Schmieden, J. Kuhse, and H. Betz, “Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA,” Science, vol. 262, no. 5131, pp. 256–258, 1993. View at Scopus
  32. F. S. Wu, T. T. Gibbs, and D. H. Farb, “Dual activation of GABA(A) and glycine receptors by β-alanine: Inverse modulation by progesterone and 5α-pregnan-3α-ol-20-one,” European Journal of Pharmacology, vol. 246, no. 3, pp. 239–246, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Gembardt, S. Grajewski, M. Vahl, H. P. Schultheiss, and T. Walther, “Angiotensin metabolites can stimulate receptors of the Mas-related genes family,” Molecular and Cellular Biochemistry, vol. 319, no. 1-2, pp. 115–123, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Marks, R. K. Datta, and A. Lajtha, “Distribution of amino acids and of exo- and endopeptidases along vertebrate and invertebrate nerves,” Journal of Neurochemistry, vol. 17, no. 1, pp. 53–63, 1970. View at Scopus
  35. F. Gejyo, Y. Kinoshita, and T. Ikenaka, “Elevation of serum levels of β-aminoisobutyric acid in uremic patients and the toxicity of the amino acid,” Clinical Nephrology, vol. 8, no. 6, pp. 520–525, 1977. View at Scopus
  36. R. Zhang, P. K. Yan, C. H. Zhou, J. Y. Liao, and M. W. Wang, “Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists,” Acta Pharmacologica Sinica, vol. 28, no. 1, pp. 125–131, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Cotecchia, “Constitutive activity and inverse agonism at the α1a and α1b adrenergic receptor subtypes,” Methods in Enzymology, vol. 485, no. C, pp. 123–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S. G. F. Rasmussen, H. J. Choi, D. M. Rosenbaum et al., “Crystal structure of the human β2 adrenergic G-protein-coupled receptor,” Nature, vol. 450, no. 7168, pp. 383–388, 2007. View at Publisher · View at Google Scholar · View at Scopus