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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 816159, 9 pages
Identification of Physiologically Active Substances as Novel Ligands for MRGPRD
1Exploratory Research Laboratories II, Daiichi Sankyo Co., Ltd., Tokyo 134-8630, Japan
2Biologics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo 134-8630, Japan
3Oncology Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan
4Department of Chemical Biology, Gunma University Graduate School of Engineering, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan
5Institute for Biomolecular Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Tokyo 171-8588, Japan
Received 22 December 2011; Revised 6 April 2012; Accepted 5 May 2012
Academic Editor: S. L. Mowbray
Copyright © 2012 Makiko Uno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. A. F. Dixon, B. K. Kobilka, and D. J. Strader, “Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin,” Nature, vol. 321, no. 6065, pp. 75–79, 1986.
- B. K. Kobilka, C. MacGregor, K. Daniel, T. S. Kobilka, M. G. Caron, and R. J. Lefkowitz, “Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes,” Journal of Biological Chemistry, vol. 262, no. 32, pp. 15796–15802, 1987.
- C. C. Felder, E. M. Briley, J. Axelrod, J. T. Simpson, K. Mackie, and W. A. Devane, “Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 16, pp. 7656–7660, 1993.
- Y. Masu, K. Nakayama, H. Tamaki, Y. Harada, M. Kuno, and S. Nakanishi, “cDNA cloning of bovine substance-K receptor through oocyte expression system,” Nature, vol. 329, no. 6142, pp. 836–838, 1987.
- M. Parmentier, F. Libert, C. Maenhaut et al., “Molecular cloning of the thyrotropin receptor,” Science, vol. 246, no. 4937, pp. 1620–1622, 1989.
- X. Dong, S. K. Han, M. J. Zylka, M. I. Simon, and D. J. Anderson, “A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons,” Cell, vol. 106, no. 5, pp. 619–632, 2001.
- P. M. C. Lembo, E. Grazzini, T. Groblewski et al., “Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs,” Nature Neuroscience, vol. 5, no. 3, pp. 201–209, 2002.
- S. Takeda, S. Kadowaki, T. Haga, H. Takaesu, and S. Mitaku, “Identification of G protein-coupled receptor genes from the human genome sequence,” FEBS Letters, vol. 520, no. 1-3, pp. 97–101, 2002.
- T. Shinohara, M. Harada, K. Ogi et al., “Identification of a G protein-coupled receptor specifically responsive to β-alanine,” Journal of Biological Chemistry, vol. 279, no. 22, pp. 23559–23564, 2004.
- W. Luo, S. R. Wickramasinghe, J. M. Savitt, J. W. Griffin, T. M. Dawson, and D. D. Ginty, “A hierarchical NGF signaling cascade controls ret-dependent and ret-independent events during development of nonpeptidergic DRG neurons,” Neuron, vol. 54, no. 5, pp. 739–754, 2007.
- L. Zhang, N. Taylor, Y. Xie et al., “Cloning and expression of MRG receptors in macaque, mouse, and human,” Molecular Brain Research, vol. 133, no. 2, pp. 187–197, 2005.
- M. J. Zylka, F. L. Rice, and D. J. Anderson, “Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd,” Neuron, vol. 45, no. 1, pp. 17–25, 2005.
- R. Fredriksson, M. C. Lagerström, L. G. Lundin, and H. B. Schiöth, “The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints,” Molecular Pharmacology, vol. 63, no. 6, pp. 1256–1272, 2003.
- S. K. Ajit, M. H. Pausch, J. D. Kennedy, and E. J. Kaftan, “Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 326020, 8 pages, 2010.
- R. Seifert and K. Wenzel-Seifert, “Constitutive activity of G-proteins-coupled receptors: cause of disease and common property of wild-type receptors,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 366, no. 5, pp. 381–416, 2002.
- D. Young, G. Waitches, and C. Birchmeier, “Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains,” Cell, vol. 45, no. 5, pp. 711–719, 1986.
- M. J. Pine, U. Kim, and C. Ip, “Free amino acid pools of rodent mammary tumors,” Journal of the National Cancer Institute, vol. 69, no. 3, pp. 729–735, 1982.
- M. Abe, M. Takahashi, and T. Nishidai, “The significance of urinary beta aminoisobutyric acid in cancer patients,” International Journal of Radiation Biology, vol. 24, no. 1, pp. 73–79, 1973.
- H. R. Nielsen, K. Nyholm, and K. E. Sjolin, “Beta-aminoisobutyric acid in urine from patients with bladder tumours,” Acta Pathologica et Microbiologica Scandinavica. Section A, vol. 78, no. 3, p. 368, 1970.
- T. P. Waalkes, C. W. Gehrke, and W. A. Bleyer, “Potential biologic markers in Burkitt's lymphoma,” Cancer Chemotherapy Reports, vol. 59, no. 4, pp. 721–727, 1975.
- T. P. Waalkes, C. W. Gehrke, and D. B. Lakings, “Beta aminoaciduria in patients with Burkitt's lymphoma,” Journal of the National Cancer Institute, vol. 57, no. 2, pp. 435–438, 1976.
- H. R. Nielsen and S. A. Killmann, “Urinary excretion of β-aminoisobutyrate and pseudouridine in acute and chronic myeloid leukemia,” Journal of the National Cancer Institute, vol. 71, no. 5, pp. 887–891, 1983.
- A. B. P. Van Kuilenburg, A. E. M. Stroomer, H. Van Lenthe, N. G. G. M. Abeling, and A. H. Van Gennip, “New insights in dihydropyrimidine dehydrogenase deficiency: A pivotal role for β-aminoisobutyric acid?” Biochemical Journal, vol. 379, no. 1, pp. 119–124, 2004.
- H. H. Tallan, S. Moore, and W. H. Stein, “Studies on the free amino acids and related compounds in the tissues of the cat,” The Journal of Biological Chemistry, vol. 211, no. 2, pp. 927–939, 1954.
- H. Fukazawa, S. Mizuno, and Y. Uehara, “A microplate assay for quantitation of anchorage-independent growth of transformed cells,” Analytical Biochemistry, vol. 228, no. 1, pp. 83–90, 1995.
- L. A. Kunz-Schughart, K. Groebe, and W. Mueller-Klieser, “Three-dimensional cell culture induces novel proliferative and metabolic alterations associated with oncogenic transformation,” International Journal of Cancer, vol. 66, no. 4, pp. 578–586, 1996.
- D. J. Calvo and R. Miledi, “Activation of GABA(ρ1) receptors by glycine and β-alanine,” NeuroReport, vol. 6, no. 8, pp. 1118–1120, 1995.
- D. Choquet and H. Korn, “Does β-alanine activate more than one chloride channel associated receptor?” Neuroscience Letters, vol. 84, no. 3, pp. 329–334, 1988.
- T. Horikoshi, A. Asanuma, K. Yanagisawa, K. Anzai, and S. Goto, “Taurine and beta-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA,” Brain research, vol. 464, no. 2, pp. 97–105, 1988.
- M. Sandberg and I. Jacobson, “β-Alanine, a possible neurotransmitter in the visual system?” Journal of Neurochemistry, vol. 37, no. 5, pp. 1353–1356, 1981.
- V. Schmieden, J. Kuhse, and H. Betz, “Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA,” Science, vol. 262, no. 5131, pp. 256–258, 1993.
- F. S. Wu, T. T. Gibbs, and D. H. Farb, “Dual activation of GABA(A) and glycine receptors by β-alanine: Inverse modulation by progesterone and 5α-pregnan-3α-ol-20-one,” European Journal of Pharmacology, vol. 246, no. 3, pp. 239–246, 1993.
- F. Gembardt, S. Grajewski, M. Vahl, H. P. Schultheiss, and T. Walther, “Angiotensin metabolites can stimulate receptors of the Mas-related genes family,” Molecular and Cellular Biochemistry, vol. 319, no. 1-2, pp. 115–123, 2008.
- N. Marks, R. K. Datta, and A. Lajtha, “Distribution of amino acids and of exo- and endopeptidases along vertebrate and invertebrate nerves,” Journal of Neurochemistry, vol. 17, no. 1, pp. 53–63, 1970.
- F. Gejyo, Y. Kinoshita, and T. Ikenaka, “Elevation of serum levels of β-aminoisobutyric acid in uremic patients and the toxicity of the amino acid,” Clinical Nephrology, vol. 8, no. 6, pp. 520–525, 1977.
- R. Zhang, P. K. Yan, C. H. Zhou, J. Y. Liao, and M. W. Wang, “Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists,” Acta Pharmacologica Sinica, vol. 28, no. 1, pp. 125–131, 2007.
- S. Cotecchia, “Constitutive activity and inverse agonism at the α1a and α1b adrenergic receptor subtypes,” Methods in Enzymology, vol. 485, no. C, pp. 123–138, 2010.
- S. G. F. Rasmussen, H. J. Choi, D. M. Rosenbaum et al., “Crystal structure of the human β2 adrenergic G-protein-coupled receptor,” Nature, vol. 450, no. 7168, pp. 383–388, 2007.