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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 845618, 10 pages
Classic and New Animal Models of Parkinson's Disease
1Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
2Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA
3Department of Neurology, Columbia University, New York, NY 10032, USA
Received 9 January 2012; Accepted 23 January 2012
Academic Editor: Monica Fedele
Copyright © 2012 Javier Blesa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [70 citations]
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- Kurt A. Jellinger, “Potential role of α-synuclein in neurodegeneration: studies in a rat animal model,” Journal of Neurochemistry, vol. 122, no. 4, pp. 659–660, 2012.
- Quinton R.D. Jones, Jordan Warford, H.P. Vasantha Rupasinghe, and George S. Robertson, “Target-based selection of flavonoids for neurodegenerative disorders,” Trends in Pharmacological Sciences, vol. 33, no. 11, pp. 602–610, 2012.
- P. Rojas, E. Ruiz-Sánchez, C. Rojas, and S.O. Ögren, “Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice,” Neuroscience, vol. 223, pp. 246–257, 2012.
- Andrea L. Nuckolls, Cole Worley, Christopher Leto, Hongyu Zhang, Jill K. Morris, and John A. Stanford, “Tongue force and tongue motility are differently affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats,” Behavioural Brain Research, vol. 234, no. 2, pp. 343–348, 2012.
- Isabelle St-Amour, Melanie Bousquet, Isabelle Pare, Janelle Drouin-Ouellet, Francesca Cicchetti, Renee Bazin, and Frederic Calon, “Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease,” Journal Of Neuroinflammation, vol. 9, 2012.
- Puneet Bagga, Anup N. Chugani, Komanduri S. Varadarajan, and Anant B. Patel, “ In vivo NMR studies of regional cerebral energetics in MPTP model of Parkinson's disease: recovery of cerebral metabolism with acute levodopa treatment ,” Journal of Neurochemistry, 2013.
- Maria Galuppo, Renato Iori, Gina Rosalinda De Nicola, Placido Bramanti, and Emanuela Mazzon, “Anti-inflammatory and anti-apoptotic effects of (R-s)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease,” Bioorganic & Medicinal Chemistry, vol. 21, no. 17, pp. 5532–5547, 2013.
- Md Shahaduzzaman, Sandra Acosta, Paula C. Bickford, and Cesar V. Borlongan, “α-Synuclein is a pathological link and therapeutic target for Parkinson’s disease and traumatic brain injury,” Medical Hypotheses, 2013.
- Ana Clara Cristóvão, Joana Barata, Goun Je, and Yoon-Seong Kim, “PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons,” Biochemical and Biophysical Research Communications, 2013.
- Paul McGonigle, “Animal Models of CNS Disorders,” Biochemical Pharmacology, 2013.
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- Adrianna Z. Herskovits, and Leonard Guarente, “Sirtuin deacetylases in neurodegenerative diseases of aging,” Cell Research, vol. 23, no. 6, pp. 746–758, 2013.
- Marina Spanos, Julie Gras-Najjar, Jeremy M. Letchworth, Audrey L. Sanford, J. Vincent Toups, and Leslie A. Sombers, “Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry,” ACS Chemical Neuroscience, vol. 4, no. 5, pp. 782–789, 2013.
- Hugo Gonzalez, Francisco Contreras, Carolina Prado, Daniela Elgueta, Dafne Franz, Sebastian Bernales, and Rodrigo Pacheco, “Dopamine Receptor D3 Expressed on CD4(+) T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease,” Journal Of Immunology, vol. 190, no. 10, pp. 5048–5056, 2013.
- Cheong-Meng Chong, Zhong-Yan Zhou, Valentina Razmovski-Naumovski, Guo-Zhen Cui, Lun-Qing Zhang, Fei Sa, Pui-Man Hoi, Kelvin Chan, and Simon Ming-Yuen Lee, “Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish,” Neuroscience Letters, vol. 543, pp. 121–125, 2013.
- Marcio Lazzarini, Sabine Martin, Mišo Mitkovski, Rita Raisman Vozari, Walter Stühmer, and Elaine Del Bel, “Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model,” Glia, 2013.
- Pádraig Mulcahy, Aideen O’Doherty, Alexia Paucard, Timothy O’Brien, Deniz Kirik, and Eilís Dowd, “The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats,” Behavioural Brain Research, vol. 243, pp. 6–15, 2013.
- Massimo S. Fiandaca, and Howard J. Federoff, “Using viral-mediated gene delivery to model Parkinson's disease: Do nonhuman primate investigations expand our understanding?,” Experimental Neurology, 2013.
- David T. Dexter, and Peter Jenner, “Parkinson disease: from pathology to molecular disease mechanisms,” Free Radical Biology and Medicine, 2013.
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- Neeta D. Grover, Ramachandra P. Limaye, Dilip V. Gokhale, and Tatyasaheb R. Patil, “Zonisamide: A review of the clinical and experimental evidence for its use in Parkinson's disease,” Indian Journal of Pharmacology, vol. 45, no. 6, pp. 547–555, 2013.
- Sudipta Chakraborty, Julia Bornhorst, Thuy T. Nguyen, and Michael Aschner, “Oxidative Stress Mechanisms Underlying Parkinson's Disease-Associated Neurodegeneration in C. elegans,” International Journal of Molecular Sciences, vol. 14, no. 11, pp. 23103–23128, 2013.
- Kaitlin F. Farrell, Sesha Krishnamachari, Ernesto Villanueva, Haiyan Lou, Tshianda N. M. Alerte, Eloise Peet, Robert E. Drolet, and Ruth G. Perez, “Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function,” Journal of Neurochemistry, 2013.
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- Gabriela P. Chaves-Kirsten, Caio H. Y. Mazucanti, Caroline C. Real, Bruna M. Souza, Luiz R. G. Britto, and Andrea S. Torrao, “Temporal Changes of CB1 Cannabinoid Receptor in the Basal Ganglia as a Possible Structure-Specific Plasticity Process in 6-OHDA Lesioned Rats,” Plos One, vol. 8, no. 10, 2013.
- Xin Zhao, Shenyu Zhai, Ming-Sheng An, Yue-Hua Wang, Ying-Fan Yang, Hui-Qi Ge, Jin-Hao Liu, and Xiao-Ping Pu, “Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson's Disease,” Plos One, vol. 8, no. 10, 2013.
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- Maja Puchades, Carl Johan Sogn, Jan Maehlen, Linda H. Bergersen, and Vidar Gundersen, “Unaltered lactate and glucose transporter levels in the MPTP mouse model of Parkinson's disease,” Journal of Parkinsons Disease, vol. 3, no. 3, pp. 371–385, 2013.
- Xian-Ming Luo, Hai Lin, Wei Wang, Marilyn S. Geaney, Lee Law, Shaun Wynyard, Shamim B. Shaikh, Henry Waldvogel, Richard L. M. Faull, Robert B. Elliott, Stephen J. M. Skinner, Jacqueline E. Lee, and Paul L. -J. Tan, “Recovery of Neurological Functions in Non-Human Primate Model of Parkinson's Disease by Transplantation of Encapsulated Neonatal Porcine Choroid Plexus Cells,” Journal of Parkinsons Disease, vol. 3, no. 3, pp. 275–291, 2013.
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- Werner J Geldenhuys, Samir M Abdelmagid, Patrick J Gallegos, and Fayez F Safadi, “Parkinson’s disease biomarker: a patent evaluation of WO2013153386,” Expert Opinion on Therapeutic Patents, pp. 1–5, 2014.
- Raffaella Adami, Giuseppe Scesa, and Daniele Bottai, “Stem cell transplantation in neurological diseases: improving effectiveness in animal models,” Frontiers in Cell and Developmental Biology, vol. 2, 2014.
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- Elena A. Kozina, Gulnara R. Khakimova, Vitaly G. Khaindrava, Valeriayn G. Kucheryanu, Nadezhda E. Vorobyeva, Alexey N. Krasnov, Sophia G. Georgieva, Lidiya Kerkerian-Le Goff, and Michael V. Ugrumov, “Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of Mptp-treated mice at the presymptomatic and symptomatic stages of parkinsonism,” Journal of the Neurological Sciences, 2014.
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- Glenda E. Gillies, Ilse S. Pienaar, Shiv Vohra, and Zahi Qamhawi, “Sex Differences in Parkinson’s Disease,” Frontiers in Neuroendocrinology, 2014.
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- Josiane W. Bortolotto, Giana P. Cognato, Raissa R. Christoff, Laura N. Roesler, Carlos E. Leite, Luiza W. Kist, Mauricio R. Bogo, Monica R. Vianna, and Carla D. Bonan, “ Long-Term Exposure to Paraquat Alters Behavioral Parameters and Dopamine Levels in Adult Zebrafish ( Danio Rerio ) ,” Zebrafish, pp. 140225122422005, 2014.
- Maria Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Maria de Lourdes Bastos, Aristidis M. Tsatsakis, José Alberto Duarte, and Félix Carvalho, “Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach,” Toxicology Letters, 2014.
- Leonard Guarente, “SIRT1 in Neurodevelopment and Brain Senescence,” Neuron, vol. 81, no. 3, pp. 471–483, 2014.
- Melissa Barker-Haliski, Daniel Friedman, H. Steve White, and Jacqueline A. French, “How Clinical Development Can, and Should, Inform Translational Science,” Neuron, vol. 84, no. 3, pp. 582–593, 2014.
- Jennifer N. Cremer, Katrin Amunts, Jochen Graw, Markus Piel, Frank Rösch, and Karl Zilles, “Neurotransmitter receptor density changes in Pitx3ak mice – a model relevant to Parkinson’s disease,” Neuroscience, 2014.
- Andrew L. Eagle, Oluyemi O. Olumolade, and Hajime Otani, “Partial dopaminergic denervation-induced impairment in stimulus discrimination acquisition in parkinsonian rats: A model for early Parkinson's disease,” Neuroscience Research, 2014.
- Florian Reinhart, Nabil El Massri, Fannie Darlot, Napoleon Torres, Daniel M Johnstone, Claude Chabrol, Thomas Costecalde, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid, and Cécile Moro, “810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice,” Neuroscience Research, 2014.
- Ulrika Nordström, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L. Joshi, Jack W. Lipton, Andrew Roholt, Satish Medicetty, Timothy N. Feinstein, Jennifer A. Steiner, Martha L. Escobar Galvis, Alain Prochiantz, and Patrik Brundin, “Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease,” Neurobiology of Disease, 2014.
- Oytun Erbaş, Bilge Piri Çınar, Volkan Solmaz, Türker Çavuşoğlu, and Utku Ateş, “The neuroprotective effect of erythropoietin on experimental Parkinson model in rats,” Neuropeptides, 2014.
- Jenny Sandstroem von Tobela, Debora Zoiab, Jorane Althaus, Paola Antinori, Julien Mermoud, Hui Song Pak, Alexander Scherla, and Florianne Monnet-Tschudi, “Immediate and delayed effects of subchronic Paraquat exposure during an early differentiation stage in 3D-rat brain cell cultures,” Toxicology Letters, vol. 230, no. 2, pp. 188–197, 2014.
- Andrzej Dekundy, Flora Mela, Martine Hofmann, and Wojciech Danysz, “Effects of dopamine uptake inhibitor MRZ-9547 in animal models of Parkinson’s disease,” Journal of Neural Transmission, 2014.
- Alvaro Martin, Cosmin A. Tegla, Cornelia D. Cudrici, Adam M. Kruszewski, Philippe Azimzadeh, Dallas Boodhoo, Armugam P. Mekala, Violeta Rus, and Horea Rus, “Role of SIRT1 in autoimmune demyelination and neurodegeneration,” Immunologic Research, 2014.
- T. R. Petrosyan, O. V. Gevorkyan, and A. S. Hovsepyan, “Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats,” Journal of Motor Behavior, vol. 46, no. 1, pp. 67–72, 2014.
- Alazne Dominguez, Blanca Suarez-Merino, and Felipe Goni-de-Cerio, “Nanoparticles and Blood-Brain Barrier: The Key to Central Nervous System Diseases,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 1, pp. 766–779, 2014.
- Pasan Fernando, Xuxu Yan, Julia Lockwood, Yin Duan, Lihui Wei, R. Glenn Wells, Corinne Bensimon, Wayne M. Mullett, and Terrence Ruddy, “Toxicological Evaluation of a Rotenone Derivative in Rodents for Clinical Myocardial Perfusion Imaging,” Cardiovascular Toxicology, 2014.
- Ramin Ansari, Ali Mahta, Eric Mallack, and Jin Jun Luo, “Hyperhomocysteinemia and Neurologic Disorders: a Review,” Journal of Clinical Neurology, vol. 10, no. 4, pp. 281, 2014.
- Slawomir Wojcik, Jan Henryk Spodnik, Edyta Spodnik, Jerzy Dziewiatkowski, and Janusz Morys, “Nigrostriatal pathway degeneration in rats after intraperitoneal administration of proteasome inhibitor MG-132,” Folia Neuropathologica, vol. 52, no. 1, pp. 41–55, 2014.