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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 870194, 5 pages
http://dx.doi.org/10.1155/2012/870194
Research Article

Ustekinumab Biotherapy and Real-Time Psoriasis Capacitance Mapping: A Pilot Study

Laboratory of Skin Bioengineering and Imaging, Department of Dermatopathology, University Hospital of Liège, 4000 Liège, Belgium

Received 10 January 2012; Accepted 1 February 2012

Academic Editor: Enzo Berardesca

Copyright © 2012 Claudine Piérard-Franchimont and Gérald E. Piérard. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering-driven dermometrology aims at improving objective and quantitative assessments of disease severity and treatment efficacy. Skin capacitance mapping/imaging is one of those emerging methods. Among its clinical applications, psoriasis capacitance mapping (PCM) was introduced in order to assess both skin scaliness and water trapping inside the stratum corneum (inflammatory serum deposits) on lesional skin. PCM was used for assessing the therapeutic effects of ustekinumab on target lesions of 5 psoriatic patients. The reduction in the inflammatory dampness of the stratum corneum was conveniently seen after a 1-month ustekinumab treatment. The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies.