About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 871272, 10 pages
Review Article

Role of Pigment Epithelium-Derived Factor in Stem/Progenitor Cell-Associated Neovascularization

1Department of Neurosurgery, School of Medicine, Chung-Shan Medical University and Hospital, Taichung 402, Taiwan
2Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
3Graduate Institutes of Integrated Medicine and Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
4Departments of Urology, Obstetrics and Gynecology, and Medical Research, China Medical University Hospital, Taichung 404, Taiwan
5Department of Anesthesiology, Tungs’ Taichung Metroharbor Hospital, Taichung 433, Taiwan
6Department of Fragrance and Cosmetic Science, and Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7School of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei 112, Taiwan

Received 12 December 2011; Accepted 26 March 2012

Academic Editor: Crispin Dass

Copyright © 2012 Jung-Tung Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.