The Immunogenicity of the Tumor-Associated Antigen α-Fetoprotein Is Enhanced by a Fusion with a Transmembrane Domain
Figure 3
Effect of T reg depletion on AFP-specific and MVA-specific CD8+ T-cell immune response. (a) Schematic of the experimental design. (b) AFP-specific CD8+ T cells from MVA-T mAFP vaccinated mice in combination with T reg depletion (⚫) or not (■) were measured by IFNg ELISpot assay. (c) MVA-specific CD8+ T cells from MVA-T mAFP vaccinated mice in combination with T reg depletion (⚫) or not (■) were measured by IFNg ELISpot assay after in vitro stimulation with the MVA-null vector. Statistical analyses were performed by the Mann-Whitney test.
