Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis

Table 1

Frequency distribution of TP53 codon 72 polymorphism genotype and association with risk of the gastric and esophageal cancers in the worldwide.

Tumor site	Country (Ethnicity)	Case/Control (n)	Genotype frequency case/Control (%)			Reference
			Arg/Arg	Arg/Pro	Pro/Pro
Esophagus	China (Asians)	758/1420	26.2/29.9	44.9/51.5	28.9/18.6	[111]
	China (Asians)	435/550	85.7/49.6	4.4/35.8	9.9/14.6	[112]
	China (Asians)	673/694	24.2/28.1	45.5/52.7	30.3/19.2	[113]
	China (Asians)	62/50	43.0/20.0	34.0/52.0	23.0/28.0	[115]
	China (Asians)	120/232	24.0/29.0	50.0/52.0	27.0/18.0	[116]
	China (Asians)	218/415	20.1/30.1	43.6/45.8	36.3/24.2	[117]
	Japan (Asians)	102/241	36.3/37.7	50.0/44.4	13.7/18.0	[118]
	South Africa (Africans)	73/115	36.0/32.0	56.0/54.0	7.0/14.0	[119]
	South Korea (Asians)	340/1700	39.4/43.2	45.6/45.6	15.0/11.2	[120]
	Taiwan (Asians)	90/254	22.2/37.0	51.1/45.7	26.7/17.3	[121]
	United States (Caucasians)	312/454	53.0/57.0	39.0/35.0	8.0/8.0	[89]
Stomach	China (Asians)	324/317	29.6/29.6	55.6/50.5	14.8/19.9	[122]
	China (Asians)	140/125	15.7/25.6	60.0/54.4	24.3/20.0	[123]
	China (Asians)	500/1000	24.6/31.6	49.0/48.6	26.4/19.8	[124]
	Japan (Asians)	144/239	35.4/37.7	48.6/44.4	16.0/18.0	[118]
	Japan (Asians)	117/116	41.9/43.1	44.4/44.8	13.7/12.1	[125]
	Korea (Asians)	2213/1700	42.4/43.2	44.1/45.6	13.4/11.2	[95]
	Korea (Asians)	292/216	34.6/41.2	43.1/47.7	22.3/11.1	[126]
	Korea (Asians)	84/43	35.7/39.5	50.0/41.9	14.3/18.6	[127]
	Taiwan (Asians)	123/126	28.5/34.1	58.5/42.1	13.0/23.8	[128]
	Italy (Caucasians)	114/295	62.3/57.3	29.8/34.6	7.9/8.1	[129]
	United States (Caucasians)	155/134	33.1/36.3	46.8/45.5	20.1/18.2	[130]
	United Kingdom (Caucasians)	120/277	47.6/45.1	45.1/46.6	7.3/8.3	[131]