Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells

Figure 1

Functions of p53 in response to DNA damage. Genomic stresses caused by ionizing radiation (IR), chemotherapy, and reactive oxygen species (ROS) activate DNA damage check point pathway, which leads to the activation of ATM and CHK2 and subsequent stabilization of p53. Then, stabilized p53 induces cell cycle arrest and DNA repair when DNA damage is moderate, whereas it activates apoptosis pathway when DNA damage is extensive.