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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 915150, 8 pages
http://dx.doi.org/10.1155/2012/915150
Review Article

Acid-Base Disorders in Patients with Chronic Obstructive Pulmonary Disease: A Pathophysiological Review

Department of Internal Medicine and Systemic Diseases, University of Catania, 95100 Catania, Italy

Received 29 September 2011; Accepted 26 October 2011

Academic Editor: Saulius Butenas

Copyright © 2012 Cosimo Marcello Bruno and Maria Valenti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.