An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC

Table 3

Catheter (CFU/catheter segment) Log reduction summary tables for day 21. Log reduction values higher than 4 are bold and underlined.

(a) For pairwise comparison, the mean Log₁₀ CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log₁₀ CFU/g recovered from the three replicates of control articles/rabbit per segment

	Sample location
	Sample no.	1	2	3	4	6	8	10
Day	Rabbit no.	Log𝑅 (pairwise comparison)
21	1	−0.47	−0.07	1.58	2.44	0.49	0.00	0.87
	𝑃	0.78	0.94	0.37	0.15	0.78	1.00	0.37
21	4*	−1.99	0.71	0.17	−0.87	1.45	1.95	0.00
	𝑃	0.23	0.76	0.93	0.50	0.27	0.27	1.00
21	7	1.84	2.38	1.31	0.97	1.03	1.03	0.00
	𝑃	0.12	0.12	0.37	0.37	0.37	0.37	1.00
21	9	−0.67	0.43	1.15	1.28	0.00	0.00	0.00
	𝑃	0.65	0.06	0.37	0.37	1.00	1.00	1.00
21	10	2.08	0.33	1.48	3.18	2.92	2.60	1.50
	𝑃	0.08	0.85	0.37	0.16	0.13	0.14	0.37

(b) For test article log reduction, the mean Log₁₀ CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log₁₀ CFU from the initial inoculum counts that were exposed to the catheters at implantation

	Sample location
	Sample no.	1	2	3	4	6	8	10
Day	Rabbit no.	Test article Log𝑅 (based on initial inoculum)
21	1	1.33	2.49	6.86	6.86	5.99	6.86	6.86
	𝑃	0.78	0.94	0.37	0.15	0.78	1.00	0.37
21	4*	4.86	5.62	5.73	5.99	6.86	6.86	6.86
	𝑃	0.23	0.76	0.93	0.50	0.27	0.27	1.00
21	7	6.86	6.86	6.86	6.86	6.86	6.86	6.86
	𝑃	0.12	0.12	0.37	0.37	0.37	0.37	1.00
21	9	5.12	3.34	6.86	6.86	6.86	6.86	6.86
	𝑃	0.65	0.06	0.37	0.37	1.00	1.00	1.00
21	10	5.12	5.89	6.86	6.86	6.86	6.86	6.86
	𝑃	0.08	0.85	0.37	0.16	0.13	0.14	0.37

(c) For control article log reduction, the mean Log₁₀ CFU/g recovered from the three replicates of control articles/rabbit was subtracted from the mean Log₁₀ CFU from the initial inoculum counts that were exposed to the catheters at implantation

	Sample location
	Sample no.	1	2	3	4	6	8	10
Day	Rabbit no.	Control article Log𝑅 (based on initial inoculum)
21	1	1.80	2.56	5.27	4.42	5.50	6.86	5.99
	𝑃	0.78	0.94	0.37	0.15	0.78	1.00	0.37
21	4*	6.86	4.90	5.55	6.86	5.40	4.90	6.86
	𝑃	0.23	0.76	0.93	0.50	0.27	0.27	1.00
21	7	5.02	4.47	5.54	5.89	5.83	5.83	6.86
	𝑃	0.12	0.12	0.37	0.37	0.37	0.37	1.00
21	9	5.79	2.90	5.71	5.58	6.86	6.86	6.86
	𝑃	0.65	0.06	0.37	0.37	1.00	1.00	1.00
21	10	3.04	5.56	5.37	3.68	3.94	4.25	5.35
	𝑃	0.08	0.85	0.37	0.16	0.13	0.14	0.37

*indicates that control catheter 3 on rabbit 4 was not available for analysis.