An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC
Table 5
Catheter (CFU/catheter segment) Log reduction summary tables for day 30. Log reduction values higher than 4 are bold and underlined.
(a) For pairwise comparison, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit per segment
Sample location
Sample no.
1
2
3
4
6
8
10
Day
Rabbit no.
Log (pairwise comparison)
30
2*
0.30
1.80
0.00
0.00
1.75
1.60
0.00
0.88
0.27
0.00
0.00
0.27
0.27
0.00
30
3
−1.72
2.98
3.43
3.49
0.87
2.71
1.19
0.34
0.10
0.00
0.00
0.37
0.12
0.37
30
5*
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
30
6**
0.00
0.00
2.60
0.00
0.00
0.00
0.00
N/A
N/A
N/A
N/A
N/A
N/A
N/A
30
8
2.49
2.56
1.97
2.40
2.38
2.40
1.13
0.12
0.12
0.12
0.12
0.12
0.12
0.37
(b) For test article log reduction, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
Sample location
Sample no.
1
2
3
4
6
8
10
Day
Rabbit no.
Test article Log (based on initial inoculum)
30
2*
5.71
6.86
6.86
6.86
6.86
6.86
6.86
0.88
0.27
0.00
0.00
0.27
0.27
0.00
30
3
4.27
5.50
6.86
6.86
6.86
6.86
6.86
0.34
0.10
0.00
0.00
0.37
0.12
0.37
30
5*
6.86
6.86
6.86
6.86
6.86
6.86
6.86
0.00
0.00
0.00
0.00
0.00
0.00
0.00
30
6**
6.86
6.86
6.86
6.86
6.86
6.86
6.86
N/A
N/A
N/A
N/A
N/A
N/A
N/A
30
8
6.86
6.86
6.86
6.86
6.86
6.86
6.86
0.12
0.12
0.12
0.12
0.12
0.12
0.37
(c) For control article log reduction, the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
Sample location
Sample no.
1
2
3
4
6
8
10
Day
Rabbit no.
Control article Log (based on initial inoculum)
30
2*
5.40
5.06
6.86
6.86
5.10
5.25
6.86
0.88
0.27
0.00
0.00
0.27
0.27
0.00
30
3
5.99
2.52
3.42
3.36
5.99
4.15
5.67
0.34
0.10
0.00
0.00
0.37
0.12
0.37
30
5*
6.86
6.86
6.86
6.86
6.86
6.86
6.86
0.00
0.00
0.00
0.00
0.00
0.00
0.00
30
6**
6.86
6.86
4.25
6.86
6.86
6.86
6.86
N/A
N/A
N/A
N/A
N/A
N/A
N/A
30
8
4.36
4.30
4.89
4.46
4.48
4.46
5.73
0.12
0.12
0.12
0.12
0.12
0.12
0.37
*indicates that control catheter 1 on rabbits 2 and 5 was not available for analysis.
**indicates that control catheters 1 and 3 on rabbit 6 were not available for analysis.
