Targeting Costimulatory Molecules to Improve Antitumor Immunity

Table 2

Clinical trials of TNF:TNFR costimulatory molecules.

Costimulatory molecule	Tumor model	Therapeutic strategy	Refs
CD40	Melanoma, Advanced cancers	CP-870,893 agonistic Ab anti-CD40	[130, 131]
	Myeloma, B-cell lymphoma, diffuse large cell lymphoma	SGN-40 agonistic Ab anti-CD40	[134–136]
	Multiple myeloma, B-cell chronic lymphocytic leukemia	HCD 122 agonistic Ab anti-CD40	[121]
4-1BB	Solid tumors	BMS-663513 agonistic Ab anti-4-1BB	[148]
OX40	Metastatic prostate cancer	Agonistic Ab anti-OX40	[37]
GITR	Melanoma	TRX518	[37]
CD30	CD30-positive lymphoma	Brentuximab vedotin Ab-drug conjugates anti-CD30	[150–153]