Table 3: Inhibitory effect of the compounds on the galactitol accumulation in rat lenses and erythrocyte.

CompoundsRat erythrocyte galactitol content ( 𝜇 M)aGalactitol content 𝜇 g/lens wet weight (g)b

Galactitol-free 0.98 ± 0.04
Control 22.8 ± 0.35844.05 ± 6.89
Quercetinc16.15 ± 0.39448.81 ± 3.38
Rosmarinic
acid (4)
15.05 ± 0.30532.38 ± 6.56
Caffeic
acid ethylene
ester (5)
15.89 ± 0.41653.76 ± 4.68

aErythrocyte was incubated in a Krebs-Ringer bicarbonate buffer containing 30 mM galactose and in the presence or absence of 5  𝜇 g/mL compounds. bMean of 3 duplication analyses of rat lens with compounds at a concentration of 5  𝜇 g/mL. cQuercetin was used as positive control. Inhibitory effect was expressed as mean ± SD of triplicate experiments.