The Inhibitory Effect of Prunella vulgaris L. on Aldose Reductase and Protein Glycation

Table 5

Inhibitory effects of the compounds isolated from the P. vulgaris L. on advanced glycation end products (AGEs).

Compounds	Concentration (𝜇g/mL)	Inhibition (%)	IC50 (𝜇M)
	196.08	66.85 ± 0.13
Aminoguanidine^a	98.04	37.39 ± 0.52	1944.86 ± 8.39
	19.61	3.96 ± 0.06
1	19.61	9.33 ± 0.27	—
2	19.61	—	—
3	19.61	—	—
4	19.61	20.67 ± 0.37	—
	9.8	74.81 ± 1.41
5	4.9	33.94 ± 0.94	33.16 ± 0.54
	1.96	9.00 ± 0.43
	98.04	88.69 ± 0.56
6	49.02	63.45 ± 1.16	304.36 ± 3.41
	19.61	9.85 ± 0.16

Inhibition rates were calculated as percentages with respect to the control value. The IC₅₀ values of each sample were estimated from the least-squares regression line of the logarithmic concentration plotted against inhibitory activity. ^aAminoguanidine was used as positive control. Inhibitory effect was expressed as mean ± SD of triplicate experiments.