Sensitive HPV Genotyping Based on the Flow-Through Hybridization and Gene Chip

Table 1

Correlation between HybriMax and HC-II in detecting HPV DNA.

Groups	Cases	Positive rate % (n)		Kappa index
		HC-II	HybriMax
Normal	79	24.0 (19)	31.6 (25)	0.75
Chronic cervicities	110	76.3 (84)	81.8 (90)	0.781
CIN I	82	82.9 (68)	80.4 (66)	0.755
CIN II	48	87.5 (42)	87.5 (42)	0.619
CINI III	56	91.1 (51)	96.4 (54)	0.548
SCC	18	100 (18)	100 (18)	—
Condyloma acuminata	20	0.5 (10)	0.4 (8)	0.8
Total	413	70.7 (292)	73.4 (303)	0.814

If Kappa index ≥ 0.75, the accordance rates were regarded as excellent; if 0.4 ≤ Kappa index ≤ 0.75, the accordance rates were regarded as good. Abbreviations: CIN I: cervical intraepithelial neoplasia grade I; CIN II: cervical intraepithelial neoplasia grade II; CINI III: cervical intraepithelial neoplasia grade III; SCC: squamous cell carcinoma.