Table 1: Proteins associated with human neurodegenerative disorders studied in yeast.

DiseaseProtein(s) involvedYeast orthologueReferences

Batten’s diseaseCLN3YHC3/BTN1[16]
Friedreich’s AtaxiaFrataxinYFH1[12, 13]
Ataxia-telangiectasiaATMTEL1, MEC1[19, 20]
Niemann-Pick diseaseNPC1NCR1[17, 18]
Hereditary Spastic ParaplegiamAAA-proteasesmAAA proteases[21]
(Afg312 and paraplegin)(Yta10 and Yta12)
Creutzfeldt-Jakob diseasePrP[23]
Amyotrophic lateral sclerosisSOD1SOD1[25]
TDP-43[27]
FUS/TLS[29, 30]
Parkinson’s diseaseα-synuclein[31]
Lrrk2[32]
Alzheimer’s diseaseAmyloid β[33, 34]
tau[35]
Huntington’s diseaseHuntingtin[41]

—: No orthologue.