Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL/6 Mice

Table 1

Obesity characteristics from mice fed with control diet (CD) or high-fat diet (HFD), supplemented or not with sunflower oil (rich in n-6 fatty acids).

	CD	HFD	CD + n6	HFD + n6
Body weight gain (g)	2.90 ± 0.42	11.30±0.91^∗	3.99 ± 0.65	10.33 ± 0.50^#
Food ingestion (g/day/animal)	3.61 ± 0.091	2.44±0.164^∗	4.53±0.158^∗	2.45 ± 0.033^#
Food efficiency (body weight gain (g)/food ingestion (g))	0.014 ± 0.06	0.083±0.022^∗	0.016 ± 0.008	0.075 ± 0.011^#
Epididymal adipose tissue (mg)	737.9 ± 89.4	1777.0±234.3^∗	555.1 ± 45.5	1450.0 ± 176.8^#

Oral supplementation with sunflower oil rich in n-6 (2 g/Kg body weight, three times a week, oral gavage) or water, started four weeks before feeding or not with HFD, maintained until the end of experimental protocol. Animals were feed with HFD or CD for additional eight weeks. Mean ± SEM (𝑛 = 8–10). Data were analyzed by two-way ANOVA and Bonferroni post-test. ^∗𝑃<0.05 versus CD; ^#𝑃<0.05 versus CD + n6.