Sunflower Oil Supplementation Has Proinflammatory Effects and Does Not Reverse Insulin Resistance in Obesity Induced by High-Fat Diet in C57BL/6 Mice

Table 2

Metabolic parameters from mice fed with control diet (CD) or high-fat diet (HFD), supplemented, or not with sunflower oil (rich in n-6 fatty acids).

	CD	HFD	CD + n6	HFD + n6
Fasted glucose (mg/dL)	186.1 ± 5.66	221.0±8.38^∗	173.8 ± 4.75	196.8 ± 10.66
GTT test (AUC)	7987 ± 779.3	13090±643.9^∗	7568 ± 1359	14790 ± 1731^#
ITT test (% glucose/min)	2.97 ± 0.19	2.13±0.21^∗	1.94±0.30^∗	1.98 ± 0.22
Total cholesterol (mg/dL)	148.2 ± 6.72	192.7±11.96^∗	164.3 ± 14.00	166.3 ± 12.33
LDL cholesterol (mg/dL)	127.4 ± 5.15	165.1±14.49^∗	128.2 ± 13.77	136.7 ± 13.22
HDL cholesterol (mg/dL)	14.73 ± 0.83	15.52 ± 1.86	19.33 ± 2.21	15.00 ± 1.15
Triglycerides (mg/dL)	68.61 ± 5.56	63.00 ± 4.40	84.70 ± 8.53	72.78 ± 8.71

Oral supplementation with n-6 (2 g/Kg body weight, three times a week, gavage) or water have started four weeks before HFD and continued until the end of experimental period. Animals were fed HFD or CD for eight weeks. GTT: glucose tolerance test; ITT: insulin tolerance test. Mean ± SEM (𝑛 = 6–15). ANOVA two-way with Bonferroni post tests. ^∗𝑃<0.05 when compared with CD; ^#𝑃<0.05 when compared with CD + n6.