Figure 5: HE-staining analysis of the degree of scaffold infiltration by granulocytes (a), lymphocytes (b), macrophages (c), giant cells (d), fibroblasts (e), capillaries (f), and collagen fibers (g) after 1, 9, and 30 days. In all implants, an increase of infiltration by lymphocytes, macrophages, giant cells, fibroblasts, capillaries, and collagen fibers could be observed at day 30 compared to day 1 postimplantation. Furthermore, a decrease of infiltrating granulocytes could be observed in all implants at day 30 compared to day 1 postimplantation. Data were calculated based on the scoring by two blinded pathologists ( per group and day; one field per slide and rat; each 5 mm2): 1 = 1–100 cells; 2 ≥ 100–200 cells; 3 ≥ 200 cells. “-”: untreated scaffold; BP: bovine pericardium (St. Jude, USA); GP: genipin; GA: glutaraldehyde; CDI: carbodiimide. Differences did not reach the level of significance.