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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 950658, 17 pages
Salinomycin as a Drug for Targeting Human Cancer Stem Cells
1Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
2Center and Network for Targeted Oncology, Clinical Research Division, Muehlackerweg 8, 69239 Heidelberg, Germany
Received 23 August 2012; Accepted 4 October 2012
Academic Editor: Adam Huczynski
Copyright © 2012 Cord Naujokat and Roman Steinhart. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [48 citations]
The following is the list of published articles that have cited the current article.
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- Won Duk Joo, Irene Visintin, and Gil Mor, “Targeted cancer therapy – Are the days of systemic chemotherapy numbered?,” Maturitas, 2013.
- Eshel Ben-Jacob, “Engineering Trojan-horse bacteria to fight cancer,” Blood, vol. 122, no. 5, pp. 619–620, 2013.
- José N. Onuchic, Patricia A. Jennings, and Eshel Ben-Jacob, “Learning from cancer how to defeat bacteria,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 9, pp. 3212–3213, 2013.
- Justin M. David, Tori A. Owens, Sonali P. Barwe, and Ayyappan K. Rajasekaran, “Gramicidin A Induces Metabolic Dysfunction and Energy Depletion Leading to Cell Death in Renal Cell Carcinoma Cells,” Molecular Cancer Therapeutics, vol. 12, no. 11, pp. 2296–2307, 2013.
- Petra Huehnchen, Wolfgang Boehmerle, and Matthias Endres, “Assessment of Paclitaxel Induced Sensory Polyneuropathy with "Catwalk" Automated Gait Analysis in Mice,” Plos One, vol. 8, no. 10, 2013.
- Olajumoke Omolara Ojo, Srikanta Kumar Rath, and Smrati Bhadauria, “Dose-Dependent Adverse Effects of Salinomycin on Male Reproductive Organs and Fertility in Mice,” Plos One, vol. 8, no. 7, 2013.
- Björn Borgström, Xiaoli Huang, Martin Pošta, Cecilia Hegardt, Stina Oredsson, and Daniel Strand, “Synthetic modification of salinomycin: selective O-acylation and biological evaluation,” Chemical Communications, vol. 49, no. 85, pp. 9944, 2013.
- Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen, and Moul Dey, “Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells,” Bmc Cancer, vol. 14, 2014.
- Wenyan Lu, and Yonghe Li, “Salinomycin Suppresses LRP6 Expression and Inhibits Both Wnt/β-catenin and mTORC1 Signaling in Breast and Prostate Cancer Cells,” Journal of Cellular Biochemistry, vol. 115, no. 10, pp. 1799–1807, 2014.
- Cristiana Pistol Tanase, Ana Iulia Neagu, Laura Georgiana Necula, Cristina Mambet, Ana-Maria Enciu, Bogdan Calenic, Maria Linda Cruceru, and Radu Albulescu, “Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics,” World Journal of Gastroenterology, vol. 20, no. 31, pp. 10790–10801, 2014.
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- Panagiota A. Sotiropoulou, Michael S. Christodoulou, Alessandra Silvani, Christel Herold-Mende, and Daniele Passarella, “Chemical approaches to targeting drug resistance in cancer stem cells,” Drug Discovery Today, 2014.
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- Rosi Bissinger, Abaid Malik, Kashif Jilani, and Florian Lang, “Triggering of Erythrocyte Cell Membrane Scrambling by Salinomycin,” Basic & Clinical Pharmacology & Toxicology, 2014.
- Justin M. David, Tori A. Owens, Landon J. Inge, Ross M. Bremner, and Ayyappan K. Rajasekaran, “Gramicidin A Blocks Tumor Growth and Angiogenesis through Inhibition of Hypoxia-Inducible Factor in Renal Cell Carcinoma,” Molecular Cancer Therapeutics, vol. 13, no. 4, pp. 788–799, 2014.
- Yonghe Li, Pui Kai Li, Michael J. Roberts, Rebecca Arend, Rajeev S. Samant, and Donald J. Buchsbaum, “Multi-targeted therapy of cancer by niclosamide: A new application for an old drug,” Cancer Letters, 2014.
- Wolfgang Boehmerle, Hanna Muenzfeld, Andreas Springer, Petra Huehnchen, and Matthias Endres, “Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice,” Journal of Molecular Medicine, 2014.
- Michal Antoszczak, Ewa Maj, Joanna Stefanska, Joanna Wietrzyk, Jan Janczak, Bogumil Brzezinski, and Adam Huczynski, “Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin,” Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 7, pp. 1724–1729, 2014.
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- Susan D. Mertins, “Cancer stem cells,” Anti-Cancer Drugs, vol. 25, no. 4, pp. 353–367, 2014.
- Jiří Hatina, “Cancer stem cells as a therapeutic target of the future,” Clinical Investigation, vol. 4, no. 4, pp. 289–291, 2014.
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- Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Vijay Kumar Ulaganathan, Annika Herrmann, Nefertiti Elnikhely, Chitra Thakur, Zhiguang Xiao, Pjotr Knyazev, Beyhan Ataseven, Rajkumar Savai, Ernst Wagner, and Andreas Roidl, “Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells,” Translational Oncology, vol. 7, no. 6, pp. 702–711, 2014.
- Feng Sang, Dongmei Li, Xiaolong Sun, Xianqiang Cao, Liang Wang, Jianlei Sun, Bingxia Sun, Lingling Wu, Guang Yang, Xiaoqian Chu, Jinghan Wang, Changming Dong, Yan Geng, Hong Jiang, Haibo Long, Sijia Chen, Guiyan Wang, Shuzhong Zhang, Quan Zhang, and Yue Chen, “Total Synthesis and Determination of the Absolute Configuration of Rakicidin A,” Journal of the American Chemical Society, pp. 141006161500002, 2014.
- Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Annika Herrmann, Ernst Wagner, and Andreas Roidl, “Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration,” Molecular Cancer, vol. 13, 2014.
- Roberto Würth, Federica Barbieri, and Tullio Florio, “New Molecules and Old Drugs as Emerging Approaches to Selectively Target Human Glioblastoma Cancer Stem Cells,” BioMed Research International, vol. 2014, pp. 1–11, 2014.
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- M. Margarida Bernardo, Alexander Kaplun, Sijana H. Dzinic, Xiaohua Li, Jonathan Irish, Adelina Mujagic, Benjamin Jakupovic, Jessica B. Back, Eric Van Buren, Xiang Han, Ivory Dean, Yong Q. Chen, Elisabeth Heath, Wael Sakr, and Shijie Sheng, “Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity,” Cancer Research, vol. 75, no. 18, pp. 3970–3979, 2015.
- Vinayak S Jamdade, Nikunj Sethi, Nitin A Mundhe, Parveen Kumar, Mangala Lahkar, and Neeraj Sinha, “Therapeutic targets of triple-negative breast cancer: a review,” British Journal of Pharmacology, 2015.
- Ishaq N. Khan, Saleh Al-Karim, Roop S. Bora, Adeel G. Chaudhary, and Kulvinder S. Saini, “Cancer stem cells: a challenging paradigm for designing targeted drug therapies,” Drug Discovery Today, 2015.
- Michał Antoszczak, Maria Sobusiak, Ewa Maj, Joanna Wietrzyk, and Adam Huczyński, “Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters,” Bioorganic & Medicinal Chemistry Letters, 2015.
- Jianxin Jiang, Huaiwen Chen, Chao Yu, Yingying Zhang, Meiyuan Chen, She Tian, and Chengyi Sun, “The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles,” Nanomedicine, vol. 10, no. 12, pp. 1863–1879, 2015.
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- Li-sen Qin, Pi-feng Jia, Zhi-qing Zhang, and Shi-ming Zhang, “ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis,” Journal of Experimental & Clinical Cancer Research, vol. 34, no. 1, 2015.
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