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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 956345, 14 pages
http://dx.doi.org/10.1155/2012/956345
Review Article

Trends in Tissue Engineering for Blood Vessels

1Regenerative Medicine Laboratory, Stem Cell Research Center, Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science, Konkuk University, 143-701 Seoul, Republic of Korea
2Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden
3Department of Orthopedic Surgery, Yonsei Sarang Hospital, 137-820 Seoul, Republic of Korea

Received 18 July 2012; Accepted 25 September 2012

Academic Editor: Brynn Levy

Copyright © 2012 Judee Grace Nemeno-Guanzon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Over the years, cardiovascular diseases continue to increase and affect not only human health but also the economic stability worldwide. The advancement in tissue engineering is contributing a lot in dealing with this immediate need of alleviating human health. Blood vessel diseases are considered as major cardiovascular health problems. Although blood vessel transplantation is the most convenient treatment, it has been delimited due to scarcity of donors and the patient’s conditions. However, tissue-engineered blood vessels are promising alternatives as mode of treatment for blood vessel defects. The purpose of this paper is to show the importance of the advancement on biofabrication technology for treatment of soft tissue defects particularly for vascular tissues. This will also provide an overview and update on the current status of tissue reconstruction especially from autologous stem cells, scaffolds, and scaffold-free cellular transplantable constructs. The discussion of this paper will be focused on the historical view of cardiovascular tissue engineering and stem cell biology. The representative studies featured in this paper are limited within the last decade in order to trace the trend and evolution of techniques for blood vessel tissue engineering.