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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 957364, 8 pages
Review Article

Multiple Metastasis-Like Bone Lesions in Scintigraphic Imaging

Ying Zhang,1,2,3,4 Chunlei Zhao,1,2,3,4,5 Hongbiao Liu,1,2,3,4 Haifeng Hou,1,2,3,4 and Hong Zhang1,2,3,4

1Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China
2Zhejiang University Medical PET Center, Hangzhou 310009, China
3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China
4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China
5Department of Nuclear Medicine, Hangzhou First People's Hospital, Hangzhou Cancer Hospital, Hangzhou 310009, China

Received 1 January 2012; Accepted 20 January 2012

Academic Editor: Mei Tian

Copyright © 2012 Ying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple benign osteolytic lesions are very hard to differentiate from disseminated bone metastasis. Whole-body bone scintigraphy (WBBS) with technetium-99m methylene diphosphonate (Tc-99m MDP) demonstrates multiple lesions with increased uptake in any bone involved. Even combined with medical history and multiple imaging results, such as MRI and CT, the clinical diagnosis of metastasis lesion remains as a challenge. These clinical characteristics are similar to multiple malignant bone metastases and therefore affect the following treatment procedures. In this paper, we analyzed multiple benign osteolytic lesions, like eosinophilic granuloma (EG), multiple myeloma (MM), disseminated tuberculosis, fibrous dysplasia, or enchondroma, occurring in our daily clinical work and concluded that additional attention should be paid before giving the diagnosis of multiple bone metastases.