Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells

<table>Antitumor effect of a combination of VPA with TMZ in glioma cell lines. Malignant glioma cell lines were treated with VPA (4 mM) or TMZ (50 <i>μ</i>M), alone or in combination, for 72 h. (a) The combination of VPA with TMZ had combined antitumor effects in U87 and U251 cells. (b) Significant enhanced antitumor effects were observed in T98 and U138 cells (TMZ-resistant glioma cell lines). Columns, mean; bars, SE.  <svg height="15.4375" id="M6" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 65.099998 15.4375" width="65.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,15.4375)">
<g transform="translate(72,-59.65)">
<text transform="matrix(1,0,0,-1,-69.87,67.83)">
<tspan style="font-size: 8.75px; " x="0" y="0">∗</tspan>
</text>
<text transform="matrix(1,0,0,-1,-64.79,61.87)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.9" y="-0.95999998">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.927885" y="-0.95999998">0</tspan>
<tspan style="font-size: 12.50px; " x="29.179386" y="-0.95999998">.</tspan>
<tspan style="font-size: 12.50px; " x="32.305138" y="-0.95999998">0</tspan>
<tspan style="font-size: 12.50px; " x="38.556637" y="-0.95999998">5</tspan>
</text>
</g>
</g>
</svg>, ANOVA. The results are representative of three independent experiments.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells 